首页 > Usbio > Usbio/TIMP-1 (Tissue Inhibitor of Metalloproteinase-1, CLGI, TIMP, TIMP1) (FITC)/100ul/215178-FITC

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Usbio/TIMP-1 (Tissue Inhibitor of Metalloproteinase-1, CLGI, TIMP, TIMP1) (FITC)/100ul/215178-FITC

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215178-FITC

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TIMP-1(TissueInhibitorofMetalloproteinase-1),asecretedglycoproteinandmemberoftheproteaseinhibitorI35(TIMP)family,isexpressedbyawiderangeofcells,includingmicrovascularendothelialcells,smoothmusclecells,mesangialcells,andsomefibroblasts.TIMP-1actsasanaturalextracellularinhibitorofMMPs(matrixmetalloproteinases),agroupofpeptidasesinvolvedindegradationoftheextracellularmatrix,andisalsoinvolvedinerythropoiesis,throughthesimulationoftheproliferation/differentiationoferythroidProgenitors.StudieshaveshownthatacorrelationbetweenlocalizedconcentrationsofTIMP-1andTIMP-3,maydeterminecellfate,andthatincreasedexpressionofTIMP-1,mayactasaninhibitor/suppressorofinvasivecellgrowth.||Applications:|SuitableforuseinELISA,WesternBlot,ImmunohistochemistryandFunctionalAssays.Otherapplicationsnottested.||RecommendedDilution:|ELISA:0.5-2.0ug/ml|WesternBlot:0.1-0.2ug/ml|Immunohistochemistry(paraffin):requiresenzymemediatedantigenretrievalpriortostainingofparrafinsections.ProteinaseKisrecomendedforthispurpose.|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Lyophilizedpowdermaybestoredat-20°C.Stablefor12monthsafterreceiptat-20°C.ReconstitutewithsterileddH2O.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Reconstitutedproductisstablefor12monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.||Note:Applicationsarebasedonunconjugatedantibody.ProductType:Pab|Isotype:IgG|Host:rabbit|Source:human|Concentration:Asreported|Form:SuppliedasaliquidinPBS,pH7.2.LabeledwithFluoresceinisothiocyanate(FITC).|Purity:Purifiedbyimmunoaffinitychromatography.|Immunogen:RecombinantproteincorrespondingtohumanTIMP-1.|Specificity:RecognizeshumanTIMP-1.||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.

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