首页 > Usbio > Usbio/SEMA3E (Semaphorin-3E, Semaphorin 3E, KIAA0331, SEMAH)/50ul/225720

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Usbio/SEMA3E (Semaphorin-3E, Semaphorin 3E, KIAA0331, SEMAH)/50ul/225720

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Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are ~750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of ~500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. SEMA3E is a secreted semaphorin with 775 amino acids. Mutations in the SEMA3E gene are associated with CHARGE syndrome, a disorder characterized by cranial nerve dysfunction, coloboma of the eye, choanal atresia, inner and external ear abnormalities, cardiac anomalies, genitourinary abnormalities, and growth retardation.||Applications: |Suitable for use in Western Blot. Other applications not tested.||Recommended Dilution:|Western Blot: 1:500-1:1000|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Pab|Isotype: IgG|Host: rabbit|Source: human|Concentration: ~1mg/ml|Form: Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.|Purity: Purified by immunoaffinity chromatography.|Immunogen: A synthetic peptide corresponding to residues in Human SEMA3E.|Specificity: Recognizes endogenous levels of SEMA3E. Species Crossreactivity: Human, mouse, rat||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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