Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn SOD/SOD1), mitochondrial manganese SOD (Mn SOD/SOD2) and extracellular Cu, Zn SOD (EC SOD/SOD3). The manganese containing 80kD tetrameric enzyme SOD2 is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain.||Applications:|Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.||Recommended Dilutions:|Western Blot: 0.5-2ug/ml. Detects MnSOD in RIPA lysates of rat L6 RIPA cells. L6 cell lysates were resolved by electrophoresis and transferred to nitrocellulose probed with S8060-10A. Proteins were visualized using an IgG (HRP) Pab Gt xRb and a chemiluminescence detection system.|Immunohistochemistry(paraffin): 10ug/ml. Detected MnSOD in paraffin embedded rat brain tissue sections.|Optimal dilutions to be determined by the researcher.||Recommended Secondary Antibodies:|I1904-39: IgG, X-Adsorbed (HRP) Pab Gt xRb|I1904-40A: IgG, H&L, X-Adsorbed (HRP) Pab Gt xRb|I1904-46Q: IgG, H&L (HRP) Pab Gt xRb||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.||Note: Applications are based on unconjugated antibody.Product Type:Pab|Isotype: IgG|Host: rabbit|Source: human|Concentration: As reported|Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).|Purity: Purified by Protein A affinity chromatography.|Immunogen: Recombinant human MnSOD (manganous superoxide dismutase)|Specificity: Recognizes human MnSOD at ~24kD. Does not react with canine. Species Crossreactivity: mouse, rat and bovine||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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