MaxLight™750 is a new Near IR stable dye conjugate comparable to DyLight™750, Alexa Fluor™700 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (759nm); Emission (780nm); Extinction Coefficient 240,000.||Human complement factor H exists in 2 forms. The most common form, of 150kD, and the less common form of 43kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.||Applications: |Suitable for use in FLISA, Immunohistochemistry, Western Blot and Flow Cytometry. Other applications not tested.||Recommended Dilutions:|Immunohistochemistry: Frozen sections|Optimal dilutions to be determined by the researcher.||Immunohistochemistry Positive Control:|Kidney from post streptococcal glomerulonephritis patients.||Recommended Secondary Antibodies:|I1904-75E: IgG1 (HRP) Pab Rb x Mo|I1904-79M: IgG1 (HRP) Pab Gt x Mo|I1904-75D: IgG1 (FITC) Pab Rb x Mo|I1904-76L: IgG1 (FITC) Pab Gt x Mo||Recommended Negative Control:|I1904-78R: IgG1 Murine Negative Control||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.||Note: Applications are based on unconjugated antibody.Product Type:Mab|Isotype: IgG1|Clone No: 7J1|Host: mouse|Source: human|Concentration: As Reported|Form: Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™750.|Purity: Purified by Protein A affinity chromatography.|Immunogen: Purified human Complement Factor H from serum|Specificity: Recognizes human Complement Factor H at ~150kD or ~43kD.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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