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Usbio//10ug/500515

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TRKA is a member of the trk proto-oncogene family and encodes a 140kD, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease.||Source:|Recombinant protein corresponding to human TRKA, fused to GST-Tag at N-terminal expressed in Insect cells.||Molecular Weight:|~66kD||Specific Activity:|22nmol/min/mg as per activity assay protocol.||Endotoxin:|<1EU/ug (LAL)||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Source: Recombinant, Insect cells|Purity: Purified (~70-90%)|Concentration: As reported|Form: Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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