Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.||Applications: |Suitable for use in Immunofluorescence, Western Blot,Immunohistochemistry, Immunocytochemistry, CHIP. Other applications not tested.||Recommended Dilution:|Immunofluorescence: 1:50-1:200|Western Blot: 1:1000-1:2000|Immunohistochemistry: 1:50-1:200|Immunocytochemistry: 1:50-1:200|CHIP: 1:50-1:200|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Mab|Isotype: IgG|Clone No: 19A78|Host: rabbit|Source: human|Concentration: Not determined |Form: Supplied as a liquid in Tris, pH 7.4, 1% BSA, 0.05% sodium azide, 40% glycerol|Purity: Purified by Protein A affinity chromatography.|Immunogen: Recombinant|Specificity: Recognizes endogenous levels of human Histone H3.3 and does not cross-react with related proteins. Species Crossreactivity: mouse and rat||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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