首页 > Stemcell > Stemcell/Anti-Human CD4 Antibody, Clone RPA-T4/APC/100-0298

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

Stemcell/Anti-Human CD4 Antibody, Clone RPA-T4/APC/100-0298

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

100-0298

品牌：

Stemcell

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

OverviewThe RPA-T4 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 - D4). The epitope for RPA-T4 has been localized to the D1 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a nonpolymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases, such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the RPA-T4 antibody blocks HIV binding and mixed lymphocyte reaction (MLR), and inhibits the activation of CD4+ T cells in vitro by interfering with the association of CD4 and HLA-DR. It also partially blocks the binding of antibody clone SK3. The epitope of the RPA-T4 antibody is reportedly sensitive to formaldehyde fixation.Subtype:Primary AntibodiesTarget Antigen:CD4Alternative Names:Leu3, L3T4, T4Reactive Species:Chimpanzee; HumanConjugation:APC; FITC; PE; UnconjugatedHost Species:MouseCell Type:T CellsApplication:CyTOF; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western BlottingArea of Interest:ImmunologyClone:RPA-T4Gene ID:920Isotype:IgG1, kappa

STEMCELL Technologies 成立于 1993 年，是加拿大最大的生物科技公司，为生命科学研究领域提供专业的细胞培养基和细胞分选产品。我们的使命是为科学的不断进步提供高品质、创新的试剂、工具和服务，本着 Scientists Helping Scientists 的精神，用我们的服务帮助您的科学研究。 STEMCELL Technologies 为全球 70 多个国家提供超过 3000 种分子生物学工具，以支持干细胞、免疫学、癌症、类器官、基因编辑、细胞治疗和再生医学等领域的科学研究。我们的 mTeSR1™、MethoCult™ 和 EasySep™ 已经成为多能干细胞培养、造血干细胞鉴定以及无柱细胞分选的金标准；许多工具为广大的科研实验室所熟知。此外，我们研发了一系列针对不同类器官的培养基，包括肠道类器官、脑类器官、肝类器官、胰类器官、上呼吸道类器官等，身体力行地推动类器官研究领域的发展。 STEMCELL Technologies，源于科研，归于科研。与您在科学的道路上携手前行！* 欲了解您区域的代理商信息，请通过电话 400-885-9050 或者邮箱 info.cn@stemcell.com 与我们联系。