MW: 228.24 Da CAS Registry #: 501-36-0 Formula: C₁₄H₁₂O₃ Target: SIRT1 Background:Resveratrol (also known as SRT-501) is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-κB; in a dose- and time-dependent manner. Description:Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol activates sirtuin subtype 1 (SIRT-1). SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation. Synonym(s): 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol Purity:

≥98% by HPLC

Solubility: Soluble in DMSO Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): 1. Svajger U, et al. Int Rev Immunol. 2012 Jun;31(3):202-22. 2. Whitlock NC, et al. Nutr Cancer. 2012;64(4):493-502.3. Juan ME, et al. Pharmacol Res. 2012 Jun;65(6):584-91.4. Turan B, et al. J Bioenerg Biomembr. 2012 Apr;44(2):281-96. Scientific Category: Deacetylase Activator Product Type: Activator/Inducer Data shown is lot-specific. Contact us for specific information on other lots.