MW: 501.8 Da CAS Registry #: 252917-06-9 Formula: C₂₂H₁₈Cl₂N₈ •HCl Target: GSK-3 Description:Hydrochloride salt of CHIR 99021, a highly selective glycogen synthase kinase-3 (GSK-3) inhibitor that can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β). Synonym(s): CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile Purity:

≥98% by HPLC

Solubility: Soluble in DMSO Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): 1. Ring et al (2003). Diabetes 52 588. 2. Pan et al (2011). Neuropsychopharmacology 36 1397. 3. Ye et al (2012). PLoS One 7 e35892. Scientific Category: Wnt Signaling Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.