MW: 420.4 Da CAS Registry #: 317-34-0 Formula: C₁₆H₂₄N₁₀O₄ Target: PDE Background:Aminophylline is a bronchodilator that is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases. Aminophylline is also a competitive adenosine receptor antagonist and it is thought to have potential therapeutic value for cardiac ischemia. Description:Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction. Synonym(s): theophylline ethylenediamine; bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine Solubility: Soluble in water (3.7 mg/ml). Solutions should be freshly prepared. Not soluble in alcohols. Format: white to off-white powder Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): 1. Crisanti, et al., Am. J. Physiol. 277, R829-R835, (1999). 2. Chanda, et al., Pol. J. Pharmacol. 50, 80-82, (1998). 3. Thakker, et al. Analytical Profiles of Drug Substances 2nd ed., (1982) 2, 1-44. Scientific Category: PDE Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.