MW: 513.49 Da CAS Registry #: 1135695-98-5 Formula: C₂₆H₂₅F₂N₃O₆ • xH₂O Target: pan-caspase Background:Q-VD-OPh is a broad spectrum caspase inhibitor that provides a cost effective, non toxic, and highly speci?c means of apoptotic inhibition and provides new insight into the design of new inhibitors. It is more stable in aqueous environments and exhibits several folds higher activity than the widely used inhibitors, ZVAD-FMK and Boc-D-FMK. Q-VD-OPh is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase 12. It can inhibit recombinant caspases 1, 3, 8, and 9 with IC50 values ranging from 25 to 400 nM, and has been shown to strongly inhibit caspases 7, 10, and 12 at higher concentrations (10 µM). Q-VD-OPh protected against the substantial apoptosis induced by actinomycin D. In addition, Q-VD-OPh alone exhibits little or no toxicity, even at extremely high concentrations. Description:Q-VD-OPH is a second-generation capase inhibitor that is highly potent, brain and cell permeable, irreversible and nontoxic. Q-VD-OPH can inhibit caspase-3 ( IC50=25 nm), caspase-1 (IC50=50 nM), caspase-8 (IC50=100 nM) and caspase-9 (IC50=430 nM). In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media, the aspartyl residue of the inhibitor is not o-methylated. Synonym(s): Q- VD-OPh; Quinolyl-Val-Asp-Oph Purity:

≥96% by HPLC

Solubility: Soluble in DMSO (10 mM) Format: white to light brown powder Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Amino Acid Sequence: Quinolyl-IE(OMe)-TD(OMe)-OPh Scientific Category: Apoptosis Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.