MW: 279.3 Da CAS Registry #: 1048371-03-4 Formula: C₁₇H₁₃NO₃ Target: PARP2 Description:UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices. Synonym(s): 5-phenacyloxy-2H-isoquinolin-1-one Purity:

≥98% by HPLC

Biological Activity: UPF 1069 is a selective inhibitor of PARP2 with IC50 of 0.3 µM. It is ~27-fold selective for PARP2 vs. PARP1 (IC50 = 8 µM). Solubility: Soluble in DMSO Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): Moroni F, et al. Br J Pharmacol. 2009;157(5):854-862 Scientific Category: PARP Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.