MW: 433.5 Da CAS Registry #: 1316214-52-4 Formula: C₂₄H₂₇N₅O₃ Target: HDAC6 Description:Rocilinostat, also known as ACY-1215, is a selective HDAC6 inhibitor with IC50 of 5 nM. It is over 10-fold more selective for HDAC6 than HDAC1, 2, 3 (class I HDACs) with slight activity against HDAC8, and minimal activity against HDAC4, 5, 7, 9, 11, SIRT1, and SIRT2. Synonym(s): Rocilinostat; ACY-1215; N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide Purity:

≥99% by HPLC

Solubility: Soluble in DMSO Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): 1. Mithraprabhu S, et al. Br J Haematol. 2013 Aug;162(4):559-62. doi: 10.1111/bjh.12388. 2. Santo L, et al. Blood. 2012 Mar 15;119(11):2579-89. Scientific Category: Deacetylase Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.