MW: 379.5 Da CAS Registry #: 1243243-89-1 Formula: C₂₅H₂₁N₃O Target: Porcupine Background:Wnt-C59 prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity, similar to Wnt inhibitors IWP-2, IWP-3 and IWP-4. But Wnt-C59 is more potent and selective, and has better chemical/physical properties, and is more suitable for in vitro/in vivo studies. Description:Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. Synonym(s): 2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide Solubility: Soluble in DMSO Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): Proffitt KD, et al. Cancer Res. 2013 Jan 15;73(2):502-7. Scientific Category: Wnt Signaling Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.