MW: 513.6 Da CAS Registry #: 957054-30-7  Formula: C₂₃H₂₇N₇O₃S₂ Description:GDC-0941, also known as Pictilisib, is a phosphatidylinositol 3-kinase (PI3K) inhibitor Synonym(s): GDC-0941, Pictilisib Purity:

≥99% by HPLC.

Biological Activity: GDC-0941 against p110a IC50=0.003µM. The IC50 for inhibiting cell proliferation in PC3 (prostate cancer) or U87MG (glioma) cells is 0.28 µM and 0.95 µM, respectively. Solubility: Soluble in DMSO at 66 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µg Format: Solid Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Folkes, A.J. et al. J. Med. Chem. 51: 5522-5532 (2008)2. Yao, E. et al. Clin. Cancer Res. 15: 4147-4156 (2009) Scientific Category: Kinase Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.