ProductName  ADisintegrinandMetalloprotease10(ADAM10),ELISAKit AlsoKnownAs  DuckADisintegrinandMetalloprotease10ELISAKit ProductGeneName  ADAM10elisakit[SimilarProducts] ResearchUseOnly  ForResearchUseOnly.Notforuseindiagnosticprocedures. RequestforManualInsert   ChromosomeLocation  Chromosome:15;NC_000015.9(58888510..59042177,complement).Location:15q22 OMIM  602192 3DStructure  ModBase3DStructureforO14672 SpeciesReactivity  Duck PreparationandStorage  Storeallreagentsat2-8degreeC ProductNote  OurELISAassaysaredynamicresearchtoolsandsometimestheymaybeupdatedandimproved.Iftheformatofthisassayisimportanttoyouthenpleasecontactourtechnicalsupportteamwithapresalesinquirybeforeplacinganorder.Wewillconfirmthecurrentdetailsoftheassay. OtherNotes  SmallvolumesofADAM10elisakitvial(s)mayoccasionallybecomeentrappedinthesealoftheproductvialduringshipmentandstorage.Ifnecessary,brieflycentrifugethevialonatabletopcentrifugetodislodgeanyliquidinthecontainer`scap.Certainproductsmayrequiretoshipwithdryiceandadditionaldryicefeemayapply. SearchableTermsforADAM10purchase  MBS051768isaready-to-usemicrowell,stripplateELISA(enzyme-linkedimmunosorbentassay)KitforanalyzingthepresenceoftheADisintegrinandMetalloprotease10(ADAM10)ELISAKittargetanalytesinBIOLOGicalsamples.TheconcentrationgrADIentsofthekitstandardsorpositivecontrolsrenderatheoreticalkitdetectionrangeinbiologicalresearchsamplescontainingADAM10.TheELISAanalyticalbiochemicaltechniqueoftheMBS051768kitisbasedonADAM10antibody-ADAM10antigeninteractions(immunosorbency)andanHRPcolorimetricdetectionsystemtodetectADAM10antigentargetsinsamples.TheELISAKitisdesignedtodetectnative,notrecombinant,ADAM10.Appropriatesampletypesmayincludeundilutedbodyfluidsand/ortissuehomogenates,secretions.Qualitycontrolassaysassessingreproducibilityidentifiedtheintra-assayCV(%)andinter-assayCV(%).NCBI/UniprotdatabelowdescribegeneralgeneinformationforADAM10.Itmaynotnecessarilybeapplicabletothisproduct. NCBIGI#  2393947 NCBIGeneID  102 NCBIAccession#  AAC51766.1[OtherProducts] UniProtPrimaryAccession#  O14672[OtherProducts] UniProtSecondaryAccession#  Q10742;Q92650[OtherProducts] UniProtRelatedAccession#  O14672[OtherProducts] MolecularWeight  84,142Da NCBIOfficialFullName  ADAM10 NCBIOfficialSynonymFullNames  ADAMmetallopeptidasedomain10 NCBIOfficialSymbol  ADAM10[SimilarProducts] NCBIOfficialSynonymSymbols  kuz;AD10;MADM;CD156c;HsT18717[SimilarProducts] NCBIProteinInformation  disintegrinandmetalloproteinasedomain-containingprotein10;CDw156;ADAM10;kuzbanianproteinhomolog;mammaliandisintegrin-metalloprotease;adisintegrinandmetalloproteasedomain10;adisintegrinandmetalloproteinasedomain10 UniProtProteinName  Disintegrinandmetalloproteinasedomain-containingprotein10 UniProtSynonymProteinNames  CDw156;Kuzbanianproteinhomolog;Mammaliandisintegrin-metalloprotease ProteinFamily  Disintegrinandmetalloproteinasedomain-containingprotein UniProtGeneName  ADAM10[SimilarProducts] UniProtSynonymGeneNames  KUZ;MADM;ADAM10[SimilarProducts] UniProtEntryName  ADA10_HUMAN NCBISummaryforADAM10  MembersoftheADAMfamilyarecellsurfaceproteinswithauniquestructurepossessingbothpotentialadhesionandproteasedomains.ThisgeneencodesandADAMfamilymemberthatcleavesmanyproteinsincludingTNF-alphaandE-cadherin.[providedbyRefSeq,Jul2008] UniProtCommentsforADAM10  ADAM10:Cleavesthemembrane-boundprecursorofTNF-alphaat'76-Ala-|-Val-77'toitsmaturesolubleform.ResponsIBLefortheproteolyticalreleaseofsolubleJAM3fromendothelialcellssurface.Responsiblefortheproteolyticreleaseofseveralothercell-surfaceproteins,includingheparin-bindingepidermalgrowth-likefactor,ephrin-A2andforconstitutiveandregulatedalpha-secretasecleavageofamyloidprecursorprotein(APP).Contributestothenormalcleavageofthecellularprionprotein.InvolvedinthecleavageoftheadhesionmoleculeL1atthecellsurfaceandinreleasedmembranevesicles,suggestingavesicle-basedproteaseactivity.ControlsalsotheproteolyticprocessingofNotchandmediateslateralinhibitionduringneurogenesis.ResponsiblefortheFasLectodomainsheddingandforthegenerationoftheremnantADAM10-processedFasL(FasLAPL)transmembraneform.AlsocleavestheectodomainoftheintegralmembraneproteinsCORINandITM2B.MayregulatetheEFNA5-EPHA3signaling.Proteintype:Celladhesion;Cellsurface;Protease;Motility/polarity/chemotaxis;EC3.4.24.81;Membraneprotein,integral;VesicleChromosomalLocationofHumanOrtholog:15q22CellularComponent:Golgiapparatus;cellsurface;focaladhesion;membrane;intracellularmembrane-boundorganelle;postsynapticdensity;cytoplasm;plasmamembrane;integraltomembrane;Golgi-associatedvesicle;nucleusMolecularFunction:integrinbinding;proteinbinding;proteinhomodimerizationactivity;zincionbinding;metallopeptidaseactivity;metalloendopeptidaseactivity;endopeptidaseactivity;proteinkinasebinding;SH3domainbinding;receptorbindingBiologicalProcess:integrin-mediatedsignalingpathway;epidermalgrowthfactorreceptorsignalingpathway;axonguidance;extracellularmatrixorganizationandbiogenesis;Notchsignalingpathway;inuteroembryonicdevelopment;constitutiveproteinectodomainproteolysis;membraneproteinectodomainproteolysis;Notchreceptorprocessing;negativeregulationofcelladhesion;positiveregulationofcellgrowth;proteinaminoacidphosphorylation;extracellularmatrixdisassembly;collagencatabolicprocess;PMA-induciblemembraneproteinectodomainproteolysis;monocyteactivation;cell-cellsignaling;positiveregulationofcellproliferation;ephrinreceptorsignalingpathway;positiveregulationofcellmigrationDisease:ReticulateAcropigmentationOfKitamura;AlzheimerDisease18 ResearchArticlesonADAM10  1.MiR-144andMir-451negativelyregulatortheADAM10proteinexpressionandmaycontributetoAlzheimerdiseasepathogenesis. Precautions  AllofMyBioSource"sProductsareforscientificlaboratoryresearchpurposesandarenotfordiagnostic,therapeutics,prophylacticorinvivouse.Throughyourpurchase,youexpresslyrepresentandwarranttoMyBioSourcethatyouwillproperlytestanduseanyProductspurchasedfromMyBioSourceinaccordancewithindustrystandards.MyBioSourceanditsauthorizeddistributorsreservetherighttorefusetoprocessanyorderwherewereasonablybelievethattheintendedusewillfalloutsideofouracceptableguidelines. Disclaimer  Whileeveryeffortsweremadetoensuretheaccuracyoftheinformationprovidedinthisdatasheet,MyBioSourcewillnotbeliableforanyomissionsorerrorscontainedherein.MyBioSourcereservestherighttomakechangestothisdatasheetatanytimewithoutpriornotice.ItistheresponsibilityofthecustomertoreportproductperformanceissuestoMyBioSourcewithin30daysofreceiptoftheproduct.PleasevisitourTerms&Conditionspageformoreinformation.

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