ProductName  ADisintegrinandMetalloprotease11(ADAM11),ELISAKit AlsoKnownAs  PigeonADisintegrinandMetalloprotease11ELISAKit ProductGeneName  ADAM11elisakit[SimilarProducts] ResearchUseOnly  ForResearchUseOnly.Notforuseindiagnosticprocedures. RequestforManualInsert   OMIM  605007 3DStructure  ModBase3DStructureforQ9UNA0 SpeciesReactivity  Pigeon PreparationandStorage  Storeallreagentsat2-8degreeC ProductNote  OurELISAassaysaredynamicresearchtoolsandsometimestheymaybeupdatedandimproved.Iftheformatofthisassayisimportanttoyouthenpleasecontactourtechnicalsupportteamwithapresalesinquirybeforeplacinganorder.Wewillconfirmthecurrentdetailsoftheassay. OtherNotes  SmallvolumesofADAM11elisakitvial(s)mayoccasionallybecomeentrappedinthesealoftheproductvialduringshipmentandstorage.Ifnecessary,brieflycentrifugethevialonatabletopcentrifugetodislodgeanyliquidinthecontainer`scap.Certainproductsmayrequiretoshipwithdryiceandadditionaldryicefeemayapply. SearchableTermsforADAM11purchase  MBS067101isaready-to-usemicrowell,stripplateELISA(enzyme-linkedimmunosorbentassay)KitforanalyzingthepresenceoftheADisintegrinandMetalloprotease11(ADAM11)ELISAKittargetanalytesinBIOLOGicalsamples.TheconcentrationgrADIentsofthekitstandardsorpositivecontrolsrenderatheoreticalkitdetectionrangeinbiologicalresearchsamplescontainingADAM11.TheELISAanalyticalbiochemicaltechniqueoftheMBS067101kitisbasedonADAM11antibody-ADAM11antigeninteractions(immunosorbency)andanHRPcolorimetricdetectionsystemtodetectADAM11antigentargetsinsamples.TheELISAKitisdesignedtodetectnative,notrecombinant,ADAM11.Appropriatesampletypesmayincludeundilutedbodyfluidsand/ortissuehomogenates,secretions.Qualitycontrolassaysassessingreproducibilityidentifiedtheintra-assayCV(%)andinter-assayCV(%).NCBI/UniprotdatabelowdescribegeneralgeneinformationforADAM11.Itmaynotnecessarilybeapplicabletothisproduct. NCBIGI#  317373326 NCBIGeneID  11096 NCBIAccession#  Q9UNA0.2[OtherProducts] UniProtPrimaryAccession#  Q9UNA0[OtherProducts] UniProtSecondaryAccession#  Q52LV4;Q9UKP2[OtherProducts] UniProtRelatedAccession#  Q9UNA0[OtherProducts] MolecularWeight  101,718Da NCBIOfficialFullName  Adisintegrinandmetalloproteinasewiththrombospondinmotifs5 NCBIOfficialSynonymFullNames  ADAMmetallopeptidasewiththrombospondintype1motif,5 NCBIOfficialSymbol  ADAMTS5[SimilarProducts] NCBIOfficialSynonymSymbols  ADMP-2;ADAM-TS5;ADAMTS-5;ADAMTS11;ADAM-TS5;ADAMTS-11;ADAM-TS11[SimilarProducts] NCBIProteinInformation  Adisintegrinandmetalloproteinasewiththrombospondinmotifs5;aggrecanase-2;adisintegrinandmetalloproteinasewiththrombospondinmotifs11;adisintegrin-likeandmetalloprotease(reprolysintype)withthrombospondintype1motif,5(aggrecanase-2) UniProtProteinName  Adisintegrinandmetalloproteinasewiththrombospondinmotifs5 UniProtSynonymProteinNames  Adisintegrinandmetalloproteinasewiththrombospondinmotifs11;ADAM-TS11;ADAMTS-11;ADMP-2;Aggrecanase-2 ProteinFamily  Disintegrinandmetalloproteinasedomain-containingprotein UniProtGeneName  ADAMTS5[SimilarProducts] UniProtSynonymGeneNames  ADAMTS11;ADMP2;ADAM-TS5;ADAM-TS5;ADAMTS-5;ADAM-TS11;ADAMTS-11[SimilarProducts] UniProtEntryName  ATS5_HUMAN NCBISummaryforADAM11  ThisgeneencodesamemberoftheADAMTS(adisintegrinandmetalloproteinasewiththrombospondinmotifs)proteinfamily.Membersofthefamilyshareseveraldistinctproteinmodules,includingapropeptideregion,ametalloproteinasedomain,adisintegrin-likedomain,andathrombospondintype1(TS)motif.IndividualmembersofthisfamilydifferinthenumberofC-terminalTSmotifs,andsomehaveuniqueC-terminaldomains.TheenzymeencodedbythisgenecontainstwoC-terminalTSmotifsandfunctionsasaggrecanasetocleaveaggrecan,amajorproteoglycanofcartilage.[providedbyRefSeq,Jul2008] UniProtCommentsforADAM11  ADAMTS5:Cleavesaggrecan,acartilageproteoglycan,andmaybeinvolvedinitsturnover.Mayplayanimportantroleinthedestructionofaggrecaninarthriticdiseases.Mayplayaroleinproteolyticprocessingmostlyduringtheperi-implantationperiod.Proteintype:Extracellularmatrix;Secreted,signalpeptide;Motility/polarity/chemotaxis;EC3.4.24.-;Protease;SecretedChromosomalLocationofHumanOrtholog:21q21.3CellularComponent:proteinaceousextracellularmatrix;endoplasmicreticulumlumen;extracellularregionMolecularFunction:integrinbinding;proteinbinding;metallopeptidaseactivity;zincionbinding;metalloendopeptidaseactivityBiologicalProcess:proteinaminoacidO-linkedglycosylation;extracellularmatrixdisassembly;extracellularmatrixorganizationandbiogenesis;cellularproteinmetabolicprocess;defenseresponsetobacterium;proteolysis;post-translationalproteinmodification ResearchArticlesonADAM11  1.psiepsilonRACKinducedupregulationofhsa-miR-377expression,coupledtodecreasesinADAMTS5andcleavedaggrecan Precautions  AllofMyBioSource"sProductsareforscientificlaboratoryresearchpurposesandarenotfordiagnostic,therapeutics,prophylacticorinvivouse.Throughyourpurchase,youexpresslyrepresentandwarranttoMyBioSourcethatyouwillproperlytestanduseanyProductspurchasedfromMyBioSourceinaccordancewithindustrystandards.MyBioSourceanditsauthorizeddistributorsreservetherighttorefusetoprocessanyorderwherewereasonablybelievethattheintendedusewillfalloutsideofouracceptableguidelines. Disclaimer  Whileeveryeffortsweremadetoensuretheaccuracyoftheinformationprovidedinthisdatasheet,MyBioSourcewillnotbeliableforanyomissionsorerrorscontainedherein.MyBioSourcereservestherighttomakechangestothisdatasheetatanytimewithoutpriornotice.ItistheresponsibilityofthecustomertoreportproductperformanceissuestoMyBioSourcewithin30daysofreceiptoftheproduct.PleasevisitourTerms&Conditionspageformoreinformation.

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