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GenWay/Insulin Growth Factor Binding Protein-2 Mouse ELISA Kit/GWB-20ACA2/96 TESTS

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GWB-20ACA2

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Description:ProductName:InsulinGrowthFactorBindingProtein-2MouseCategory:GrowthFactorsSampleType:SerumSensitivity:0,04ng/MlDescription:EnzymeImmunoassayforQuantitativeDeterminationofMouse-Insulin-likeGrowthFactorBindingProtein-2.#ofSamples:1X96AssaysIntendedUse:ThisIGFBP-2EnzymeImmunoassay-KitissuitedforquantitativedeterminationofIGFBP-2inmouseserumforscientificpurposes.Severalratsera(3differentones)wereusedinthisassay,butnoIGFBP-2couldbeproved.Introduction:Insulin-likegrowthfactors(IGFs)regulatetheproliferation,differentation,apoptose,celladhesionandmetabolisminvarioustissuesandcelltypes.TheIGF-I,whichisproducedmainlyinliverundertheinfluenceofGrowthHormone(GH),regulatesashormonethelineargrowthofthebonesandtheprocessofsexualmaturity,whileIGF-IIismainlyagrowthfactoroffoetaltissue(11-13).TheBIOLOGicalactionsofIGFovertheIGF-Type-IreceptoraremodulatedvariablythroughtheIGFbindingproteins(IGFBP-1to-6)(14).IGFBP-2is,afterIGFBP-3,thesecondmostfrequentIGFBPinthehumanblood.IGFs,especiallytumortypicalpro-IGF-formsandhormonesregulatetheexpressionofIGFBP-2,GHeffectistherebyinhibiting.AtcellularlevelIGFBP-2seemstostimulatetheproliferationanddisseminationofsolidtumorsviaanIGF-independentmechanism(15,16).TechnicalFeatures+Applications:-HighlyspecificandsensitiveassayforquantitativedetectionofIGFBP-2inmouseserum-RecombinantmouseIGFBP-2asstandard-UsesantibodiesagainstcompletemouseIGFBP-2-Nosampleextractionisrequired-Detectionlimit:0.04ng/mlProductName:InsulinGrowthFactorBindingProtein-2MouseFunction:IGF-bindingproteinsprolongthehalf-lifeoftheIGFsandhavebeenshowntoeitherinhibitorstimulatethegrowthpromotingeffectsoftheIGFsoncellculture.TheyaltertheinteractionofIGFswiththeircellsurfacereceptors.Subunit:BindsIGF2morethanIGF1.SubcellularLocation:Secreted.Similarity:Contains1IGFBPN-terminaldomain.Similarity:Contains1thyroglobulintype-1domain.AdditionalInformation:NameInsulinGrowthFactorBindingProtein-2MouseELISAKitRelatedProductNamesInsulinGrowthFactorBindingProtein-2MouseELISAKit;IGF-bindingprotein2;IGFBP-2;IBP-2BP2;IBP2InsulinGrowthFactorBindingProtein-2MouseIGFBP-2MolecularWeight35138SwissProtNumberP18065IntendedUseResearchUseOnly

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