

提醒:代购产品,无质量问题不接受退换货,下单前请仔细核对信息。下单后请及时联系客服
核对商品价格,订单生效后再付款。
GenWay/Free PSA/GWB-2E3483/1x96 Assays
价格:
自营商城
解放采购
正品保障
及时交付
厂家直采
一站服务
货号:
品牌:
会员服务:
尊享会员价
贵宾专线
运费优惠
闪电退款
福利优惠
上门换新
友情提示
以上价格仅为参考,请联系客服询价。
免费咨询热线
4000-520-616
产品说明
Description:ProductName:FreePSA#ofSamples:1x96AssaysIntendedUse:FreePSAkitisadirectsolidphaseenzymeimmunoassayforquantitativedeterminationoffreeProstaticSpecificAntigen(fPSA)inhumanserum.Introduction:ProstateSpecificantigen(PSA)isaserineproteasewithchymotrypsin-likeactivity.Theproteinisasinglechainglycoproteinwithamolecularweightof28.4kDA.PSAderivesitsnamefromtheobservationthatitisanormalantigenoftheprostratebutisnotfoundinanyothernormalormalignanttissue.PSAisreleasedfromthenormalprostateandappearsatlowserumconcentrationsinhealthymen.Studieswithreversetranscription-PCRhaveshownthatPSAalsoisexpressedatalowconcentrationinperipheralbloodcellsandothertissues.Highserumconcentrationscanbedetectedinpatientswithadvancedprostatecancer(PCA).ThereforePSAisappliedasatumorMarkerfortheclinicalmanagementofPCA.However,increasedPSAconcentrationsinserumalsooccurinpatientswithbenignprostatehyperplasia(BPH).HencethegoalistodiscriminateclearlybetweenBPHandPCAintheclinicallaboratorytosparethepatientinvasivediagnosticprocedures,suchasaprostatebiopsy.InhumanserumPSAoccursintwoforms:freePSA(f-PSA)andcomplexedPSA.ThemajorformisacomplexofPSAandα1-antichymotrypsin(ACT).Thefractionoff-PSAwasshowntobesubstantiallysmallerinpatientswithuntreatedPCAthaninpatientswithBPH.Thereforecombinedmeasurementsoff-PSAandtotalPSA(t-PSA)mayleadtoabetterdiscriminationbetweenBPHandPCA.Somerecentstudieshavealreadyshownthatthef-PSA/t-PSAratioishelpfulinthedifferentialdiagnosisofBPHandPCA.PSAisfoundinbenign,malignantandmetastaticprostratecancer.Sinceprostatecanceristhesecondmostprevalentformofmalemalignancy,thedetectionofelevatedPSAlevelsplaysanimportantroleintheearlydiagnosis.SerumPSAlevelshavebeenfoundtobemoreusefulthanprostaticacidphosphatase(PAP)inthediagnosisandmanagementofpatientsduetoincreasedsensitivity.Principlesoftheassay:Inthismethod,standards,patientspecimensand/orcontrols(containingthenativefPSAantigen)arefirstaddedtostreptavidincoatedwells.Biotinylatedmonoclonalandenzymelabelledantibodiesarethenaddedandthereactantsaremixed:theseantibodieshavehighaffinityandspecificityandaredirectedagainstdistinctanddifferentepitopesoffPSA.StorageandStABIlity:Theclosedreagentsarestableuptotheexpirydatestatedonthelabelwhenstoredat+2
+8°Cinthedark.Openedreagentsarestablefor60dayswhenstoredat+2
+8°C.LimitationsoftheTest:Bacterialcontaminationorrepeatedfreeze-thawcyclesofthespecimenmayaffecttheabsorbancevalues.ReferencesChristenssonA,LaurellCB,LiljaH.,EurJBiochem,194,755-63(1990).WattKW,et.al.,ProcNatAcadSciUSA,83,3166-70(1986).ChenZ,PrestiglacomoA,StameyT.,ClinChem,,41,1273-82(1995).WildD,TheImmunoassayHandbook.,StocktonPressp452(1994).JunkerR,BrandtB,ZechelC,AssmannG,ClinChem,43,1588-94(1997).PrestigiacomoAF,StameyTA,Physiologicalvariationsofserumprostateantigeninthe(4-10ng/ml)rangeinmalevolunteers.J.Urol(1996);155:1977-80.StameyTA,McNealJE,YemotoCM,SigalBM,JohnstoneIM,BIOLOGicaldeterminantsofcancerprogressioninmenwithprostatecancer.JAMA(19999;281:1395-1400.ChenZ,PrestigiacomoA,StameyT,PurificationandcharacterizationofProstateSpecificAntigen(PSA)Complexedtoa1-Anticymotrypsin:PotentialreferenceMaterialforInternationalStandardizationofPSAImmunoassays.ClinChem.(1995);41/9:1273-1282.HortonGL,BahnsonRR,DattM,CfhanKM,CatalonaWJandLandensonJH.DifferencesinvaluesobtainedwithtwoassaysofProstateSpecificAntigen.J.Urol.(1988);139:762-72.StenmanUH,LeinonenJ,AlfthanH,RannikkoS,TuhkanenKandAlfthanO.Acomplexbetweenprostatespecificantigenanda1-anticymotrypsinisthemajorformofprostatespecificantigeninserumofpatientswithprostatecancer:assayofcompleximprovesclinicalsensitivityforcancer.CancerRes.(1991);51:222-26.AdditionalInformation:NameFreePSARelatedProductNamesFreePSAMolecularWeight0.5StorageTheclosedreagentsarestableuptotheexpirydatestatedonthelabelwhenstoredat+2
+8°Cinthedark.Openedreagentsarestablefor60dayswhenstoredat+2
+8°C.IntendedUseResearchUseOnly
GenWay生物科技是一家领先的蛋白质和抗体解决方案供应商。自1998年以来,他们已经提供蛋白质的解决方案和应用研究。迄今为止,GenWay生物科技的在圣地亚哥工厂产生了数以千计的蛋白质和抗体。公司致力于为客户提供研究界最好的试剂。如果产品不符合既定的规格,公司将全额退款。
新品排行榜
1
GenWay/Mouse Kappa Light Chain A...
2
GenWay/Goat Anti-Rabbit IgM (u h...
3
GenWay/Measles IgM ELISA/GWB-CF5...
4
GenWay/Rhodamine Conjugated Affi...
5
GenWay/MAGIC RED CATHEPSIN L KIT...
6
GenWay/Annexin V-Cy5 Apoptosis K...
7
GenWay/Anti Deamidated Gliadin P...
8
GenWay/Rat IgG Antibody (Mouse A...
9
GenWay/Annexin V-Cy5 Apoptosis K...
10
GenWay/Annexin V-Cy5 Apoptosis K...
文章排行榜
1
GenWay/Borrelia burgdorferi IgM recombinant antigens + liquor/GWB-C3EBD6/1x96 Assays
2
GenWay/Interferon Gamma ELISA Kit/GWB-E3FBA9/96 TESTS
3
GenWay/Adenovirus IgG/GWB-C22CDD/1x96 Assays
4
GenWay/Mouse IGF-1 ELISA Kit/GWB-SKR077/96 Tests
5
GenWay/Tris Buffered Saline Wash Solution - 10X Concentrate/GWB-98F288/
6
GenWay/Alpha-Fetoprotein (AFP) Enzyme Immunoassy Test Kit/GWB-C3BE7B/ELISA_Kits
7
GenWay/Anti-MPO (p-ANCA)/GWB-521206/1x96 Assays
8
GenWay/CaspGLOW Fluorescein Active Caspase-8 Staining Kit - 25 assays/GWB-AXR137/25 assays
9
GenWay/USP2 (E. coli) Active Human Recombinant Protein/GWB-PS5BBC/100µg
10
GenWay/NEK7, Active Human Recombinant Protein/GWB-PS7203/10µg