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GenWay/Rubella Virus IgG quantitative/GWB-31CB3E/1x96 Assays

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GWB-31CB3E

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Description:PleaseclickhereforMSDSPDFDatasheetProductName:RubellaVirusIgG–ELISA#ofSamples:1x96AssaysIntendedUse:TheRubellavirusIgG-ELISAisintendedforthequantitativedeterminationofIgGclassantibodiesagainstRubellavirusinhumanserumorplasma(citrate).Introduction:RubellaisanenvelopedRNAvirusbelongingtothetogaviruses.Ithasasphericalshapemeasuringabout50-70nmindiameter.Thereappearstobeonlyoneantigenictype,andnocross-reactivitywithalphavirusesorothermembersofthetogavirusgrouphasbeenfound.Rubellavirusesarepathogensoftherespiratorytractandtransmittedmainlybydropletinfection.Rubellaisaworldwidecommoncontagiousdiseasewithmildconstitutionalsymptomsandageneralizedrush.Inchildhood,itisaninconsequentialillness,butwhenitoccursduringpregnancy,thereisasignificantriskofseveredamagetothefoetus.Theriskofcongenitalrubelladependsprimarilyonthemonthofpregnancyinwhichinfectionisacquired:overall,app.16%ofinfantshavemajordefectsatbirthfollowingmaternalrubellainthefirst3monthsofpregnancy.Congenitalrubellainfectionmayleadtoasyndromewithsingleormultipleorganinvolvements,knownasembryopathiarubeolosa.Insomecasesinfectionisinapparentbutresultsinconsequentialdamagesaseyedefects,deafness,growthretardation,andothers.Naturallyacquiredimmunityusuallyislong-lasting,butreinfectionispossIBLeduetodecreasinglevelsofcirculatingantibodies.Forimmunizationavaccinecontaininglivevirusisused.InfectionmaybeidentifiedbyDetectionofvirusbyPCR(prenatal)Hemagglutinationinhibition(HAI),Haemolysis-in-geltest(HiG)DetectionofantibodiesbyEIA,ELISAPrinciplesoftheassay:ThequantitativeimmunoenzymaticdeterminationofIgG-classantibodiesagainstRubellaVirusisbasedontheELISA(Enzyme-linkedImmunosorbentAssay)technique.MicrotiterstripwellsareprecoatedwithRubellaVirusantigenstobindcorrespondingantibodiesofthespecimen.AfterwashingthewellstoremoveallunboundsamplematerialhorserADIshperoxidase(HRP)labelledanti-humanIgGconjugateisadded.ThisconjugatebindstothecapturedRubella-specificantibodies.TheimmunecomplexformedbytheboundconjugateisvisualizedbyaddingTetramethylbenzidine(TMB)substratewhichgivesabluereactionproduct.TheintensityofthisproductisproportionaltotheamountofRubellaspecificIgGantibodiesinthespecimen.Sulphuricacidisaddedtostopthereaction.Thisproducesayellowendpointcolour.Absorbanceat450nmisreadusinganELISAmicrowellplatereader.StorageandStABIlity:Thereagentsarestableuptotheexpirydatestatedonthelabelwhenstoredat2...8°C.LimitationsoftheTest:Bacterialcontaminationorrepeatedfreeze-thawcyclesofthespecimenmayaffecttheabsorbancevalues.Diagnosisofaninfectiousdiseaseshouldnotbeestablishedonthebasisofasingletestresult.Aprecisediagnosisshouldtakeintoconsiderationclinicalhistory,symptomatologyaswellasSEROlogicaldata.Inimmunocompromizedpatientsandnewbornsserologicaldataonlyhaverestrictedvalue.ReferencesReefSe.,FreyTk.,TheallK.,AabernathyE.,BurnettCl.,IcenoglJ.,McCauleyMm.,WhartonM.Thechangingepidemiologyofrubellainthe1990s:onthevergeofeliminationandnewchallengesforcontrolandprevention.JAMA.2002Jan23-30;287(4):464-72.MezzasomaLBacarese-HamiltonT.,DiChristinaM.,RossiR.BistoniF.,CrisantiA.Antigenmicroarraysforserodiagnosisofinfectiousdiseases.ClinChem.2002Jan;48(1):121-30.CooperLz.Currentlessonsfrom20thcenturyserosurveillancedataonrubella.ClinInfectDis.2001Oct15;33(8):1287.SignoreC.Rubella.Prim.CareUpdateObGyns.2001Jul;8(4):133-137.WeberB.Currentdevelopmentsinthelaboratorydiagnosisofrubella.BullSocSciMedGrandDucheLuxemb.1997;134(2):31-41.Voller,A.andD.E.Bidwell.1975.Asimplemethodfordetectionantibodiestorubella.Brit.J.Exp.Pathology56:338339AdditionalInformation:NameRubellaVirusIgGquantitativeRelatedProductNamesRubellaVirusIgG–ELISAMolecularWeight0.5StorageThereagentsarestableuptotheexpirydatestatedonthelabelwhenstoredat2...8°C.IntendedUseResearchUseOnly

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