Harlan Teklad 2018  global 18% protein rodent dietsHarlan Teklad动物饲料Harlan代理–上海金畔生物科技有限公司欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。2018年全球18%蛋白质啮齿类饲料Home + Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Standard natural ingredient diets + Rodent diets + 2018 Teklad global 18% protein rodent dietsDesigned to support gestation, lactation, and growthFormulated to reduce soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal dietsTypical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from 150 to 250 mg/kgExclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imagingclarityAbsence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)Not all products are stocked locally; extended lead time and additional fees may apply.Many diets are available in certified format designated by a \"C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.Harlan代理–上海金畔生物科技有限公司欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。Teklad diet, bedding and enrichment    Teklad laboratory animal diets   Custom research diets   NAFLD and NASH诱导啮齿动物NAFLD/NASH的饮食方法可分为两大类：长期喂饲可诱发肥胖、代谢综合症及轻微纳什或短时间喂饲可诱发严重纳什的肝脏特征而不引起肥胖或胰岛素抵抗的饮食。下表突出了上述两个类别的饮食选择。有关NAFLD/NASH模型的更完整描述，请参见表后面的下拉菜单。Dietary methods to induce NAFLD/NASH in rodents can be split into two common categories:diets fed for longer periods of time to induce obesity, metabolic syndrome, and mild NASH ordiets fed for short periods of time to induce hepatic features of severe NASH without inducing obesity or insulin resistanceThis page provides further information on dietary methods to induce NAFLD/NASH. We ve also prepared a downloadable NASH/NAFLD mini paper.The tables below highlight diet options from both of the above categories. For more complete descriptions of NAFLD/NASH models see the drop down menus that follow the tables.Western or fast food style diets fed to induce NASH with metabolic syndrome contain 40 45% kcal from milkfat (a fat source high in palmitate) with added cholesterol (0.15 – 2%) and are high in sucrose ( 30%). Dietary palmitate and cholesterol have both previously been associated with the progression from simple steatosis to NASH.Examples:TD.88137       Adjusted Calories Diet (42% from fat)TD.96121       21% MF, 1.25% Chol. DietTD.120528     42% Kcal/Fat Diet (Incr. Sucrose, 1.25% Chol.)Research use:These diets can induce obesity, metabolic syndrome, and simple steatosis within nine weeks of feeding. Increased hepatic inflammation has been observed after 12 weeks of feeding. NASH typically requires longer feeding with fibrosis developing within nine months and late stage fibrosis including hepatic ballooning occurring after 14 – 20 months of feeding. Increasing dietary sucrose (~41%) and cholesterol (~1.25%) accelerates the NASH phenotype with steatosis, inflammation and hepatocyte ballooning observed within 12 weeks. In addition to feeding a high fat diet, providing a glucose/fructose mixture in the drinking water may further promote NASH development.Select References:Charlton, M., et al., Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol, 2011. 301(5): p. G825-34. http://www.ncbi.nlm.nih.gov/pubmed/21836057Gores, G., Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, McConico A, Masuoko H. Am J Physiol Gastrointest Liver Physiol, 2015. 308: p. G159. http://ajpgi.physiology.org/content/308/2/G159Li, Z.Z., et al., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem, 2009. 284(9): p. 5637-44. http://www.ncbi.nlm.nih.gov/pubmed/19119140Ioannou, G.N., et al., Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis. J Lipid Res, 2009. 54(5): p. 1326-34. http://www.ncbi.nlm.nih.gov/pubmed/23417738Alkhouri, N., et al., Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem, 2010. 285(5): p. 3428-38. http://www.ncbi.nlm.nih.gov/pubmed/19940134Dixon, L.J., et al., Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One, 2013. 8(2): p. e56100. http://www.ncbi.nlm.nih.gov/pubmed/23409132DeLeve, L.D., et al., Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol, 2008. 173(4): p. 993-1001. http://www.ncbi.nlm.nih.gov/pubmed/18772330VanSaun, M.N., et al., High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol, 2009. 175(1): p. 355-64. http://www.ncbi.nlm.nih.gov/pubmed/19541928Asgharpour, A., et al., A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol, 2016. 65(3): p. 579-88. http://www.ncbi.nlm.nih.gov/pubmed/27261415Tetri, L.H., et al., Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol, 2008. 295(5): p. G987-95. http://www.ncbi.nlm.nih.gov/pubmed/18772365Tsuchida, T., et al., A simple diet-and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. Journal of hepatology, 2018. 69(2):385-395. https://www.ncbi.nlm.nih.gov/pubmed/29572095The American Lifestyle-Induced Obesity Syndrome (ALIOS) model involves feeding the \"American fast food” diet high in trans-fats and sugar. Dietary trans-fats from hydrogenated vegetable shortening (HVO) are associated with increased insulin resistance and hepatic inflammation in rodent NASH models. In addition to diet, a glucose/fructose solution is added to the drinking water and sedentary behavior promoted by removing the overhead cage feeders in this model.Examples:TD.06303       22% HVO DietTD.120330     22% HVO + 0.2% Cholesterol DietTD.130885     ALIOS with Added SugarResearch use:The ALIOS model develops obesity with insulin resistance, elevated ALT levels, and steatosis within 16 weeks. Increased inflammation and early development of fibrosis have been observed at 6 months. Severe steatosis with fibrosis and inflammation develops within 12 months of feeding with 50% of the mice reportedly developing hepatic neoplasms. Adding cholesterol (0.2%) to the American Fast Food diet may accelerate NASH phenotype development.Select References:Koppe, S.W., et al., Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol, 2009. 297(2): p. G378-84. http://www.ncbi.nlm.nih.gov/pubmed/19541924Tetri, L.H., et al., Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol, 2008. 295(5): p. G987-95. http://www.ncbi.nlm.nih.gov/pubmed/18772365Mells, J.E., et al., Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol, 2012. 302(2): p. G225-35. http://www.ncbi.nlm.nih.gov/pubmed/22038829Dowman, J.K, et al., Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. Am J Pathol, 2014. 184(5):1550-1561. https://www.ncbi.nlm.nih.gov/pubmed/24650559 Mells, J.E., et al., Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. J Nutr Biochem, 2014. 26(3): p. 285-92. http://www.ncbi.nlm.nih.gov/pubmed/25577467The Fructose, Palmitate, Cholesterol and Trans-Fat (FPC) diet is a recent NASH diet that includes Western and ALIOS model diets to achieve both metabolic and hepatic NASH features within an accelerated time frame. Key features of the FPC diet include 1) a lower Met content than typical rodent diets by decreasing total protein without supplementing sulfur amino acids; 2) choline supplementation is lower than typical but is not considered deficient; 3) high in sucrose (~34% by weight); 4) 1.25% cholesterol; 5) 52% kcal from fat with fat sources including milkfat fat, palmitic acid and hydrogenated vegetable shortening to provide trans-fats. Like the ALIOS model, the FPC model also provides a glucose/fructose solution to the drinking water.Examples:TD.160785     52 kcal/Fat Diet (C16:0, HVO, AMF, Choline/Met)Research use:Male C57BL/6J mice fed the FPC diet and provided a glucose/fructose drinking solution developed insulin resistance and NAFLD with inflammation, hepatocyte death, and fibrosis within 16 weeks.Select References:Wang, X., et al., Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis. Cell Metab, 2016. 24(6): p. 848-62. https://www.ncbi.nlm.nih.gov/pubmed/28068223  Zhu, C., et al., Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. Sci Transl Med, 2018. 10(468). https://www.ncbi.nlm.nih.gov/pubmed/30463916Common diets to induce obesity (DIO) can be fed to induce uncomplicated NAFLD. These high fat diets typically contain 40–60% kcal from fat without supplemented cholesterol or cholate. Simple sugars such as sucrose or fructose can also be supplemented via diet or water to progress the fatty liver phenotype. Diets can be in pellet or powder/dough form depending on the formula. Some models require limited physical activity and in those cases diets can be fed inside the cage. For more information see our Diet Induced Obesity page.Examples:TD.08811       45%kcal Fat Diet (21% MF, 2% SBO)TD.06414       Adjusted Calories Diet (60/Fat)Research use:In susceptible rodent models, high fat diets are commonly used to induce NAFLD with obesity and insulin resistance common metabolic features associated with NASH in humans. However, the degree of NASH pathology (steatosis, inflammation, and fibrosis) is limited or mild and varies depending on the animal model, length of feeding, and dietary components.Originally formulated to induce mild atherosclerosis in wild-type rodents, high fat diets containing added cholesterol (1 – 1.25%) and cholate (0.5% as sodium cholate or cholic acid) have also been useful in inducing NASH. This diet option includes purified \"Western” style diets with increased cholesterol and cholate and also hybrid diets. Hybrid diets were originally developed by Beverly Paigen and colleagues by mixing a natural ingredient mouse diet in a 3:1 ratio with a concentrated purified diet (containing 5% cholesterol and 2% sodium cholate) resulting in a diet containing ~15.8% fat, 1.25% cholesterol, and 0.5% sodium cholate. Although a less refined approach, the hybrid diet is associated with increased gallstone formation and liver damage as compared to similar purified diets.Examples:TD.02028       Atherogenic Rodent DietTD.88051       Cocoa Butter Diet and Purina Mouse ChowTD.09237       15% AMF Diet (1% Chol, 0.5% NaChol)Research use:Atherogenic diets are able to induce varied degrees of NASH with increased hepatic inflammation with early fibrosis observed after ten weeks of feeding. However, the metabolic profile typical in human NASH (obesity with insulin resistance) is not recapitulated in this model with animals typically maintaining similar body weights as control fed groups without the development of metabolic syndrome.Select References:Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69. http://www.ncbi.nlm.nih.gov/pubmed/2380634Kamari, Y., et al., Lack of interleukin-1alpha or interleukin-1beta inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. J Hepatol, 2011. 55(5): p. 1086-94. http://www.ncbi.nlm.nih.gov/pubmed/21354232Kim, D.G., et al., Non-alcoholic fatty liver disease induces signs of Alzheimer s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model. J Neuroinflammation, 2016. 13: p. 1. http://www.ncbi.nlm.nih.gov/pubmed/26728181Madrigal-Perez, V.M., et al., Preclinical analysis of nonsteroidal anti-inflammatory drug usefulness for the simultaneous prevention of steatohepatitis, atherosclerosis and hyperlipidemia. Int J Clin Exp Med, 2015. 8(12): p. 22477-83. http://www.ncbi.nlm.nih.gov/pubmed/26885230Savransky, V., et al., Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. Am J Physiol Gastrointest Liver Physiol, 2007. 293(4): p. G871-7. http://www.ncbi.nlm.nih.gov/pubmed/17690174Methionine and choline deficient (MCD) diets are amino acid defined rodent diets deficient in methionine and choline, high in sucrose ( 40% by weight) with ~10% corn oil by weight. Methionine and choline deficiency decreases fat oxidation and export of fat from the liver. Dietary sucrose is necessary for hepatic lipid accumulation and oxidation. The polyunsaturated fat in corn oil promotes hepatic lipid oxidation.Example:TD.90262       Methionine/Choline Deficient DietControl:TD.94149       Amino Acid Control DietResearch use:Steatosis, increased serum alanine aminotransferase (ALT), inflammation, and hepatic fat oxidation has been observed within three weeks of feeding the MCD diet with fibrosis development after six weeks. This dietary model does not produce metabolic syndrome (an aspect of NASH in human models) and progressive weight loss (up to 40%) is associated with the MCD diet feeding.蛋氨酸/胆碱缺乏症(MCD)日粮蛋氨酸和胆碱缺乏(MCD)饲料是一种氨基酸定义的啮齿动物饲料，缺乏蛋氨酸和胆碱，蔗糖含量高(体重 40%)，玉米油含量约10%。蛋氨酸和胆碱缺乏减少脂肪氧化和从肝脏输出脂肪。日粮蔗糖对肝脏脂质的积累和氧化是必需的。玉米油中的多不饱和脂肪促进肝脏脂质氧化。例子：TD.90262 蛋氨酸/胆碱缺乏症饮食管制：TD.94149 氨基酸控制饮食研究用途：观察到脂肪变性、血清丙氨酸转氨酶(ALT)升高、炎症和肝脂肪氧化反应。这种饮食模式不会产生代谢综合症(在人类模型中是NASH的一个方面)和累进性减肥(高达40%)与MCD饮食喂养有关。Select References:Pickens, M.K., et al., Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis. J Lipid Res, 2009. 50(10):2072-82.  http://www.ncbi.nlm.nih.gov/pubmed/19295183Li, Z.Z., et al., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem, 2009. 284(9): p. 5637-44. http://www.ncbi.nlm.nih.gov/pubmed/19119140Lee, G.S., et al., Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury. J Lipid Res, 2007. 48(8): p. 1885-96. http://www.ncbi.nlm.nih.gov/pubmed/17526933Vetelainen, R., A. van Vliet, and T.M. van Gulik, Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model. J Gastroenterol Hepatol, 2007. 22(9): p. 1526-33. http://www.ncbi.nlm.nih.gov/pubmed/17716355Leclercq, I.A., et al., Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone. Lab Invest, 2007. 87(1): p. 56-65. http://www.ncbi.nlm.nih.gov/pubmed/17075577Kashireddy, P.R. and M.S. Rao, Sex differences in choline-deficient diet-induced steatohepatitis in mice. Exp Biol Med (Maywood), 2004. 229(2): p. 158-62. http://www.ncbi.nlm.nih.gov/pubmed/14734794Dixon, L.J., et al., Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab Invest, 2012. 92(5): p. 713-23. http://www.ncbi.nlm.nih.gov/pubmed/22411067Dietary models of NAFLD/NASH continue to evolve with the goal of more accurately recapitulating both the metabolic and hepatic symptoms of human disease. Commonly researchers are studying the synergistic effects of various NASH dietary features to accelerate progression of the model and severity of liver disease.A Teklad nutritionist can work with you to formulate new diets in order to investigate novel dietary models of NAFLD/NASH.The choice of control diet is dependent on the specific research goal. Many researchers choose to compare their NAFLD/NASH diet-fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diet or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens).Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component. In some cases, such as those studies feeding amino acid defined diets like the MCD model, a matched control diet is recommended given the very different formulations and protein sources of grain-based diets.When making inferences about specific nutrients within the diet an ingredient matched, low fat control diet may be necessary. There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined and digestible) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible).A very basic purified control diet would be AIN-93M TD.94048 or AIN-93G TD.94045. AIN-93 diets have a moderate amount of sucrose at ~10% with fat from soybean oil providing a healthy fatty acid profile.Contact a nutritionist for an additional information and control diet recommendations.对照日粮控制饮食的选择取决于具体的研究目标。许多研究人员选择比较他们的NAFLD/纳什饮食喂养的动物和喂养一种天然成分的动物，谷物为基础的饮食(也称为标准饮食或周食)。这些饮食在营养来源和水平以及非营养因素(如植酸盐或植物雌激素)存在的情况下存在差异。根据您的主要比较，它可能适合作为您的对照/参考组谷物基础的饮食。然而，这样的比较限制了对饮食模式和特定饮食成分的推断。在某些情况下，如那些研究喂食氨基酸定义的饮食，如mcd模型，建议一个匹配的对照饮食，考虑到非常不同的配方和蛋白质来源的谷物为基础的饮食。当对饮食中的特定营养成分做出相应的推断时，低脂控制饮食可能是必要的。除了不同类型的碳水化合物外，还有许多不同水平和类型的脂肪，从蔗糖(高精制和可消化)到玉米淀粉(精制，但更复杂)，再到抗性淀粉(精制，但不能完全消化)。一种非常基本的纯正控制饮食将是-9300万。TD.94048或者是93g TD.94045。AIN-93日粮中含有适量的蔗糖~10%，大豆油中的脂肪提供了健康的脂肪酸谱。Harlan代理–上海金畔生物科技有限公司欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。FootnoteThe 2018 Teklad Global diet with 1% added choline from choline chloride (approx. 85% choline).Selected Nutrient Information1Box labeled with product name, manufacturing date, and lot numberReplace diet at minimum once per weekMore frequent replacement may be advisedLead time:2 weeks non-irradiated4 weeks irradiated图片仅供参考,请以实物为准。正文中列出的所有试剂只能用于测试或研究，不能作为 药品 ， 食品 ， 家庭用品 等使用。我司所销售的化学试剂、原料等所有产品（包括但不限于抗生素类、蛋白质类、试剂盒类产品等）仅限用于科学研究用途，不得作用于人体。 Harlan Teklad动物饲料分类Harlan Teklad代理，Harlan Teklad动物饲料代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。Standard natural ingredient diets  标准天然成分饮食Rodent diets  啮齿类食物Dog diets  狗粮Rabbit diets   兔饲料Guinea pig diets    豚鼠日粮Primate diets  灵长类饮食Swine diets  猪日粮Other dietsCustom research diets  定制研究饮食Ordering and services  订购和服务NAFLD and NASH    NAFLD和NASHAIN diet formulas   AIN饮食配方Atherogenic    动脉粥样硬化AtherogenicDiet can be a useful tool to induce or accelerate atherosclerosis in laboratory animal models. Key dietary features used to induce atherosclerosis in rodents vary depending on the research model, desired endpoint, and length of feeding. While formulations of atherogenic diets continue to evolve, the options that are well-described in the literature are summarized below. For more information on each diet option and literature references see the expandable tabs following the diet table.Accelerated hypercholesterolemia and plaque formation in genetically modified models such as Apoe and Ldlr deficient mice.Used for diet induced obesity in a variety of rodent models.High fat diet (20 23% by weight; 40 45% kcal from fat)Saturated fatty acids (SFA 60% of total fatty acids)Milkfat/butterfatSucrose (34% by weight)Cholesterol (0.2% total)Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.Will not promote obesity.High fat diet (15 20% by weight; 34 45% kcal from fat)Saturated fatty acids (SFA 55% of total fatty acids)Milkfat/butterfat, cocoa butterSucrose (30-50% by weight)Cholesterol (1 1.25%)Cholate Source (0.5%)*Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.Will not promote obesity.Also used for lithogenic (gallstone) rodent studies.75% rodent breeder diet; 25% purified ingredientsHigh fat (~15% by weight; 37% kcal from fat)Saturated fatty acids (SFA 45% of total fatty acids)Cholesterol (1.25%)Cholate source (0.5%)*Induce hypercholesterolemia in genetically modified and wild type models without promoting obesity.*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available.Mineral adjusted diets  矿物调节饮食NaCl adjusted (natural ingredient)  盐调节(天然成分)Amino acid defined  氨基酸定义Doxycycline diets  多西环素饮食Tamoxifen diets  他莫昔芬饮食Customer supplied ingredients  客户供应的配料Basal mixes  基混合体Isoflavone adjusted  异黄酮调节Rabbit, swine and other species  兔子、猪和其他物种Diet ingredients  饮食成分Medicated diets  药物饮食Teklad medicated lab animal diets are manufactured either at a subsidiary plant or at our custom research diet facility. Contact customer service or your local Envigo account representative for pricing and availability of stocked diets. Contact a nutritionist to discuss customized versions of these or other medicated diets.Medicated diets must be used as directed by a veterinarian. Harlan Teklad 动物饲料 Vitamin A Diet(25,000)说明书Harlan Teklad动物饲料Harlan代理–上海金畔生物科技有限公司欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。FoothoteThis modification of diet AIN-93G (TD.94045) replaces vitamin A palmitate withtamin A acetate and increases the total concentration to approximately 25,000/kg. Alcohol-extracted casein is substituted for regular casein.Selected Nutrient InformationValues are calculated from ingredient analysis or manufacturer dataKey Features+ Purifield   Diet+Vitamin A+AlN 93G Modification+ RodentKey Planning Information+ Product are made Fresh fo order+ store product at 4° C or IoWer+ Use within 6 months(appIicable to most diets)+ Box Labeled with product namemanufaGturing date,and Iot number+ Replace diet at nninimunη once per weekationHarlan代理欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。These formulas are purified diets with commonly used refined ingredients. These basic formulas are often modified for a specific research purpose, such as altering the fat source, a vitamin or mineral level, or adding a compound. See the FAQ section to learn more about the history of these formulas, AIN-76A, AIN-93G, and AIN-93M.CA.170481 AIN-76A purified dietTD.94045 AIN-93G purified dietTD.94048 AIN-93M purified dietThese formulas (as well as other purified diets) do not contain alfalfa and can be used to reduce background autofluorescence in certain imaging applications. Our Global Rodent Diets are also alfalfa-free and are suitable for imaging work. Please contact us for further information about these formulas or modifications.Other related product codes:TD.94096 version of AIN-76A suitable for irradiation (vitamin levels are increased)TD.97184 version of AIN-93G suitable for irradiation (vitamin levels are increased)TD.00102 version of AIN-93M suitable for irradiation (vitamin levels are increased)TD.95092 modification of AIN-93G where soybean oil is replaced with corn oil.Harlan AIN diet formulas这些配方是含有常用精制成分的纯正饮食。这些基本配方通常是为特定的研究目的而修改的，例如改变脂肪来源、维生素或矿物质水平，或添加一种化合物。见常见问题了解更多关于这些公式的历史的章节，AIN-76A，AIN-93g，和AIN-93m。CA.170481AIN-76A纯饲料TD.94045AIN-93g纯饲料TD.9404893米纯饲料这些配方(以及其他纯化饲料)不含苜蓿，可用于减少背景自荧光在某些成像应用中。我们的全球啮齿动物饮食也是无苜蓿的，适合成像工作.有关这些公式或修改的进一步信息，请与我们联系。其他相关产品代码：TD.94096适合辐照的AIN-76A版本(维生素含量增加)TD.97184适合辐照的an-93g版本(维生素含量增加)TD.00102AIN-93m适合辐照的版本(维生素含量增加)TD.95092用玉米油代替大豆油的n-93g改性。Harlan代理欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Custom research diets + Diet ingredientsYou may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.Our ingredientsWe offer several ingredients for individual sale so that you can develop your own blends.\"VFT” casein\"Vitamin-free” test casein (alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlledThe reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname Vitamin-free was given to the extracted casein many years agoVitamin mixesThe common vitamin mixes shown below use sucrose or corn starch as a carrierCustomized vitamin mixes may use cellulose if a non-nutritive carrier is necessaryVitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animalFor those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a dietVitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 monthMinimum order is 500 g for both stock and custom vitamin mixesOur available vitamin mixes are commonly used in diets, and are available from stockVitamin mixes are shipped within a few days of orderOur Formula examplesCA.40060 Teklad vitamin mixCA.40077 AIN-76A vitamin mixTD.94047 AIN-93 vitamin mixMineral mixesThe common mineral mixes shown below as examples use sucrose as a carrierCustomized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessaryOur mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animalFor those preparing their own diets, mineral premixes are an efficient way to add minerals to a dietMineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixesThese mineral mixes are commonly used in diets, and are available from stockOur mineral mixes are shipped within a few days of orderFormula examples:CA.170915 AIN-76 mineral mixTD.94046 AIN-93G mineral mixTD.94049 AIN-93M mineral mixOther mixes (may or may not be available from stock):TD.83171 Vitamin mix without A, D, E, cholineTD.81062 Iron deficient mineral mix based on AIN-76ATD.79055 Calcium and phosphorus deficient mineral mixed based on AIN-76TD.98057 Calcium and phosphorus deficient mineral mixed based on AIN-93CA.170760 Rogers-Harper mineral mix你可能想要在你的研究地点或设施准备你自己的饮食，如果是这样的话，你取决于成分是最高的质量。Envigo可以为您提供许多相同的成分，用于生产我们先进的特克拉德定制研究饮食，以便您可以开发自己的配方。和往常一样，我们的营养专家在这里帮助您为您的配料和最终配方做出佳决定。我们的配料我们提供几个配料供个人销售，以便您可以开发自己的混合。\"VFT”酪蛋白\"无维生素”测试酪蛋白(酒精提取)最适合于那些需要精确控制脂肪或维生素含量的纯正试验饮食配方。VFT酪蛋白中许多维生素含量的降低使得它成为许多维生素研究的首选蛋白质来源。因此，\"无维生素”的绰号是在许多年前给提取出来的酪蛋白起的。维生素混合物以下常见的维生素混合物使用蔗糖或玉米淀粉作为载体。定制的维生素混合物可能使用纤维素，如果非营养载体是必要的。维生素混合物的制定考虑到了饮食中的包容率。多用或少用会损害你的实验动物的健康。对于那些自己准备饮食的人来说，维生素预混剂是向饮食中添加维生素的一种有效方法。维生素混合物应储存在4摄氏度或更低的接收。如果使用时间超过1个月，建议使用摄氏-20度。库存和定制维生素混合物的最低订购量为500克。我们可用的维生素混合物通常用于饮食，并可从库存中获得。维生素混合物在订购后几天内发货。我们的公式示例CA.40060 特克拉德维生素混合物CA.40077 AIN-76A维生素混合物TD.94047 AIN-93维生素混合物矿物混合物下面所示的常见矿物混合物是以蔗糖为载体的。如果需要非营养的载体，定制的矿物混合物可以使用纤维素，也可以不使用载体。我们的矿物质混合物是根据饮食包容率来制定的。多用或少用会损害动物的健康。对于那些自己准备饮食的人来说，矿物预混料是向饮食中添加矿物质的有效方法。矿物混合物应存放在干燥、凉爽的环境中，并在收到后一年内使用。库存和自定义矿物混合物的最低订购量为500克。这些矿物混合物通常用于饮食，并可从库存中获得。我们的矿物混合物在订货后几天内装运。公式示例：CA.170915 AIN-76矿物混合物TD.94046 AIN-93g矿物混合物TD.94049 AIN-9300万矿物混合物其他混合材料(可能从库存中获得，也可能无法从库存中获得)：TD.83171不含A，D，E，胆碱的维生素混合物TD.81062基于AIN-76A的缺铁矿物配料TD.79055 AIN-76混合钙磷缺乏矿物TD.98057AIN-93混合钙磷缺乏矿物CA.170760 罗杰斯-哈珀矿物混合物图片仅供参考,请以实物为准。正文中列出的所有试剂只能用于测试或研究，不能作为 药品 ， 食品 ， 家庭用品 等使用。我司所销售的化学试剂、原料等所有产品（包括但不限于抗生素类、蛋白质类、试剂盒类产品等）仅限用于科学研究用途，不得作用于人体。 Harlan代理 TD.80396 Iron Deficient Diet 缺铁饲料说明书Harlan Teklad动物饲料Harlan代理 上海金畔生物科技有限公司欢迎新老客户访问Harlan官网或者咨询我们上海金畔生物获取更多详细资料。Harlan Teklad Custom DietHarlan TD.80396  Iron Deficient DietFootnoteThe diet contains approximately 2-6 ppm Fe. To limit background iron, cellulose is omitted, and reagent grade, pretested calcium phosphate is used in the mineral mix. TD.80394 is a possible ingredient matched control with ~48 ppm added iron from ferric citrate. For questions about this or other iron adjusted dietsSelected Nutrient Information1Use within 6 months (applicable to most diets)Box labeled with product name, manufacturing date, and lot numberReplace diet at minimum once per weekMore frequent replacement may be advisedLead time:2 weeks non-irradiated4 weeks irradiatedProduct Specific Information1/2 Pellet or Powder (free flowing)Minimum order 3 KgIrradiation not advisedContact a nutritionist for recommendationsHarlan代理 上海金畔生物科技有限公司欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。Harlan Teklad Custom DietHarlan TD.85419  Zinc Deficient DietFootnoteEgg white solids are used instead of casein to reduce background zinc. The zinc content of the diet ranges from approximately 0.5 1.5 ppm. TD.85420 is a possible ingredient matched control with ~50ppm zinc from zinc carbonate. For questions about this or other zinc adjusted dietsSelected Nutrient InformationUse within 6 months (applicable to most diets)Box labeled with product name, manufacturing date, and lot numberReplace diet at minimum once per weekMore frequent replacement may be advisedLead time:2 weeks non-irradiated4 weeks irradiatedProduct Specific Information1/2 Pellet or Powder (free flowing)Minimum order 3 KgIrradiation available upon request Harlan Teklad动物饲料问与答 Diet FAQs上海金畔生物代理Harlan饲料，欢迎访问Harlan官网或者咨询我们获取更多相关产品信息。Standard Natural Ingredient DietsA more complete name would be Standard Natural Ingredient Diets. These diets are manufactured in large quantities (at least 2 tons) and stocked at one or more Envigo Teklad distribution centers. Standard natural ingredient diets are readily available and can generally be delivered within a few days after an order is placed. These diets primarily contain grains (corn, wheat), legumes (soybean meal) and to a lesser extent ingredients such as fish meal, and meat and bone meal. Standard natural ingredient diets include Global and Traditional diets and are available Irradiated and/or Certified.Using standardized fixed formulas and ingredients purchased under the same stringent specifications in the United States and Europe, Envigo s unique Teklad Global Diets Program provides nutritional consistency to national and multinational companies for their worldwide research, maximizing global study uniformity. Global Diets have the same product names in all countries. The Global Rodent diets have lower protein levels than most traditional diets and are formulated free of alfalfa with zero or modest amounts of soybean meal, thus minimizing the presence of natural phytoestrogens.Envigo offers a variety of Traditional Teklad diets for the common laboratory animal species. These fixed formula diets are made from high quality ingredients. While traditional diets will supply the known nutrient needs of laboratory animals, we recommend that researchers consider the use of a diet from our Global Diet line. The traditional rodent diets were formulated decades ago based on understanding of rodent nutrition, ingredients, and diet manufacturing at the time. There was limited appreciation of the effects of non-nutrients, such as phytoestrogens, on experimental results. Alfalfa meal and soybean meal are the major sources of phytoestrogens in laboratory animal diets. These ingredients, particularly soybean meal, are found in most traditional rodent diets.Fixed Formula diets are diets that are manufactured in accordance with a formula that remains unchanged from one production to the next. In conjunction with strict quality standards for raw materials, this approach ensures quality and consistency by minimizing nutrient variability and the variability of other phytochemicals in the diet which might affect a research study.Certified diets are diets that have been tested for a standard panel of environmental contaminants that are known to be capable of interfering with a study. These diets help ensure that a study complies with the FDA’s Good Laboratory Practices regulations requiring periodic feed analysis. An Envigo certificate of analysis signed by a nutritionist is made available to the customer.6. How does Envigo ensure the high quality and consistency of Teklad Global and Traditional standard diets?Our #1 goal is to provide quality and consistent products to our customers. This begins with ensuring that raw materials of only the highest consistency and quality are obtained. Raw materials are only obtained from approved suppliers who agree to meet our quality standards. Suppliers are audited on a regular basis and their products are tested for quality before being accepted into our facilities. Fixed formulas and established manufacturing procedures are in place for each product which ensure that the product is manufactured consistently with each production. In-process and final product testing is completed prior to distribution of the product to a customer. Envigo utilizes its own network of company owned and operated distribution centers throughout the US and Canada rather than use outside distributors.There is no definitive point where one is able to predict when a specific diet will spoil or become deficient in one or more nutrients. The common guideline of a 6 month shelf life is based on longstanding practice in North America. In Europe and Asia, differences in local practices and regulatory oversight have led to Teklad standard natural ingredient diets being routinely used out to 9 months and sometimes 12 months post-manufacture. This practical experience, along with literature support and vitamin testing over time, gives us confidence that these diets continue to support animal health and study integrity out to at least 9 months post-manufacture. Please refer to your institution for guidance if you are unsure of local policies.没有一个人能够预测当特定的饮食会破坏或缺乏一个或更多的营养。在常见的 6 个月的货架寿命是基于长期的实践中。在欧洲和亚洲 ， 不同地方的做法和监管标准 ， 导致 Teklad 饮食天然成分通常使用了 9 个月和 12 个月后有时制造。这种实践的经验 ， 再加上文学和测试支持 ， 让我们继续支持这些膳食研究动物的健康和完整性至少 9 个月后制造。请参考您的机构的指导 ， 如果你不确定的地方政策。Recommended storage conditions:Cool and dry; at or below 70 degrees Fahrenheit, humidity below 50% ideal, but up to 65% is acceptableClean and free of pestsIn original packaging or in a container that prevents continuous exposure to light and minimal exposure to air建议贮藏条件 ：冷却和干燥 ；在等于或低于 70 华氏度 ， 湿度低于 50% ， 但高达 65 ％ 是可接受的干净 ， 没有害虫在原包装或容器 ， 防止在连续的光暴露和最小暴露于空气中Envigo offers irradiated diets, bedding, and enrichment items. Irradiation reduces the bioburden (number of organisms) contained by a product by exposing the product to gamma ionizing radiation from cobalt-60. Organisms exposed to gamma irradiation are damaged at the molecular level often with lethal effects. The net result is a decrease in the amount of viable microorganisms present in the product. Envigo irradiates all Teklad products at a minimum dose of 2.0 Mrad (20kGy) and a maximum of 5.0 Mrad (50 kGy).Autoclaving destroys vitamins and amino acids that are supplemented in the diet. To compensate for this destruction, autoclavable diets contain an additional supplement of vitamins and supplemental amino acids. Autoclavable diets are packaged in perforated bags which allow steam from the autoclave to penetrate throughout the diet when the diet is autoclaved inside the bag.Phytoestrogens are phytochemicals naturally produced by plants which interact with endogenous estrogens. They have some similarity in molecular structure compared to endogenous estrogens and bind to some extent with estrogen receptors. Phytoestrogens have been shown to affect mammalian physiology including cancer growth, atherosclerosis, calcium-phosphorus metabolism, and behavior. This is of concern to researchers because standard natural ingredient diets are often composed of ingredients which contain significant quantities of phytoestrogens. Soybean meal is an ingredient common to standard natural ingredient diets which contains a class of phytoestrogens called isoflavones. The two primary isoflavones are genistein and daidzein. Alfalfa meal is a second ingredient common to standard natural ingredient diets. It contains the phytoestrogen coumestrol.Custom research diets are made in small quantities and are generally not stocked. These diets are typically formulated for a specific type of research objective. These diets can consist of refined ingredients (purified diets), natural ingredients (grain and other ingredients found in standard diets), or utilize a standard diet as a base to which other ingredients are added. Any of these diet types can serve as the basis to add a customer supplied ingredient (test article, pharmaceutical, food extract, etc). We have approximately 20,000 diets in our database, so the formula you require may already have been created. We also utilize this database as a resource when formulating new diets. We will be pleased to provide you a complete formula sheet, containing the ingredients and inclusion rate, macronutrient values, key features, and planning and ordering information.Purified diets use refined ingredients such as casein, sucrose, cornstarch, and cellulose. These human food grade ingredients have relatively simple chemical compositions (predominantly one nutrient classification) and this feature is important for manipulating individual nutrients for research purposes. Additionally, most refined ingredients contain very limited levels of non-nutrients that could have biological activity. This is in contrast to the natural ingredients (corn, wheat, soybean meal, etc.) used in standard diets, which have relatively complex chemical compositions as well as various phytochemicals that may or may not be physiologically relevant. Refined ingredients are obtained from reliable suppliers of human grade products, and we consistently obtain ingredients from the same vendors, year after year. Additionally, the major protein ingredients are assayed for a specific panel of nutrients to ensure minimal variation. Thus, purified diets will be repeatable and can easily be modified. Examples of common purified diets include AIN-76A (CA.170481), AIN-93G (TD.94045), and AIN-93M (TD.94048).The American Society for Nutrition (ASN) (formerly American Institute of Nutrition, AIN) has promoted the use of nutritionally adequate purified diets for rodents, because many researchers may not be aware of potential nutritional variables. The AIN-76 formula was published in 1977, and became AIN-76A with minor revision (increased Vitamin K) in 1980. The diet has been used extensively, and there were several suggestions about improvements. This resulted in the publication of two formulas in 1993, AIN-93G (for growth, reproduction, and lactation) and AIN-93M (for maintenance). The article J. Nutr. 123: 1939-1951 (1993) discusses the rationale for the several revisions. Some of the changes include soybean oil rather than corn oil, the addition of other carbohydrate sources and lower sucrose, decreased phosphorus, cystine in place of methionine, inclusion of several trace mineral elements, and a few vitamin adjustments. The maintenance diet has less protein and fat.15. How does Envigo ensure the high quality and consistency of Teklad custom research diets?envigo 如何保证产品质量的一致性和 Teklad 饮食风俗研究 ？Each formula is given a unique identification number and retains that identity among the thousands of formulas in our files. This assures the same formula will be used even years later. Upon production, a six or seven-digit Rx lot number is assigned that allows for traceability through all phases of diet production. These detailed production records are kept for every item produced. Quality-control samples are retained for nine months. Each lot of the major protein ingredients is analyzed for a number of nutrients to verify uniformity from lot to lot. Care is taken to retain reputable vendors for these refined ingredients.每个配方给出唯一身份识别号码 ， 并保存到文件在我们的公式。这确保了即使使用相同的公式。在生产、 6 或 7 位 \"RX” 批号被分配以允许所有饲料生产。这些详细的生产记录 ， 每一个项目。质量控制样本的 9 个月。每个批次的蛋白质是主要成分分析的一定数量的营养物 ， 以验证批次与批次之间一致性。要注意保留这些成分精制的著名厂商。16. Can Envigo add test compounds to diets?Yes, we can help you in adding a test compound or ingredient to a diet. This is often a convenient approach to dosing research animals. When adding a compound to a diet, there are some important safety and stability considerations. Please see customer supplied ingredients for more specific information.A phone call or an email exchange with one of our staff will augment the information that you gather from the web site or published literature, and you are more likely to receive a diet that best meets your particular needs. We are careful to maintain confidentiality, and will sign formal agreements if necessary. Please contact us at info@jinpanbio.com for consultation regarding your specific diet needs.Advise us why the diet is needed, and for what animal species. Discuss the nutrients or ingredients of interest in as much detail as possible. Please avoid subjective descriptions such as low, normal, and high because these terms have different meanings to various researchers. Provide us with a copy of any existing formula to be duplicated or modified, and any journal article(s) upon which your research may be based. Let us know if the diet must be irradiated.Our minimum order for custom research diets is 3 kg. This is particularly convenient when feeding small numbers of mice, especially for diet that contains your test compound. The minimum quantity for vitamin and mineral mixes is 500 g.我们的饮食风俗研究最少是 3 公斤。这是特别方便的小数量喂养、饮食含有测试化合物。在最小量的维生素和矿物质混合料是 500 克。Prices are dependent on formula details, ingredient composition, order quantity, and form (pellet or powder). If you know the product code, contact customer service at  info@jinpanbio.com. If you are unsure of the product code, have a new request, or require other technical information, contact a Nutritionist info@jinpanbio.com.Standard packaging includes a small box (nine x nine x 11 inches) that will fit up to five kg, a medium box (ten x ten x 15 inches) that will fit up to ten kg, and a larger heavy-duty box (13 x 13 x 20 inches) with inset handles that holds up to 20 kg. Every container also includes a three-mil poly liner to keep your research diet as fresh as possible. Vacuum packaging and specific quantity packaging are also available at additional cost. Vacuum packaging will typically reduce the amount of diet fit into a box. Contact us at info@jinpanbio.com for more information.标准包装包括小盒 (9 x 9 x 11 英寸) ， 安装 5 千克、介质盒 (10 x 10 x 15 英寸) 适合为 10 公斤 ， 大的重负荷箱 (13 × 13 × 20 英寸) ， 以使保持高达 20 公斤。每个容器还包括一个 3 密耳衬层来研究饮食尽可能新鲜。真空封装和包装特定数量的附加成本。真空封装将典型地减少饮食中的盒。22. How long after I place my order will I receive my custom diet?多久以后我还会收到产品订单定制饮食 ？Diets are custom made to fill each order. The typical lead-time between order and shipment is ten business days. The exceptions to this are TD.88137, TD.06414, and TD.01306 which for orders of 25 kg or less, are usually available within a week. If irradiation is required (add ten business days). We can often accommodate your rush production needs, for an additional fee. Contact us at info@jinpanbio.com for more details. Transit time depends on the type of delivery method used (regular ground, overnight, etc.). Weight and delivery method affect shipping costs, which are typically prepaid and added to the invoice.饮食是每个自定义填充命令。在典型的订单和发货时间为十个工作日。在 td.88137 ，td.06414， 和td.01306对其订单的 25 kg 或更少、通常是可用的。如果需要增加照射 （ 十个工作日 ） 。我们经常可以容纳你急生产需要 ， 需增加额外的费用。23. What is the shelf life of custom research diets?There is no definitive point where one is able to predict when a specific diet will spoil or become deficient in one or more nutrients. Custom research diets are perishable and should be refrigerated at 4 degrees celsius (40 degrees fahrenheit) or lower (see Fullerton, et.al. J Nutr. 112:567-573, 1982). As a general guideline, diets can be stored this way for up to six months. Freezing a diet may slow reactive processes, but there is not sufficient information available to recommend feeding a diet past six months as a general guideline. Use of diets beyond the recommended use date will be subject to the protocols of your institution.没有一个人能够预测当特定的饲料会破坏或缺乏一个或更多的营养。饲料习俗研究很容易腐烂并冷藏在 4 ℃ 或更低 (参见 Fullerton 等。J Nutr 。112 ： 567 573 ， 1982) 。作为一般性指导 ， 可这种方法存放六个月之久。冷冻的食物可减慢反应过程 ， 但是没有足够的信息可用以推荐的饮食喂养 6 个月。使用饲料建议的使用日期的协议。Custom research diets vary significantly in their formulation. There may be certain features of a diet that merit a shorter shelf-life. To learn more about storage and use recommendations, and to help you asess if your diet has features that may warrant a shorter shelf-life we have put together a guide. If you have further questions about your diet, contact us at info@jinpanbio.com.Barrier facilities or certain animal models require sterilized diet. Most custom research diets do not withstand autoclaving; however, we can arrange for qualified diets to be irradiated. The irradiation dose range is two to five MRad, or 20-50 kGy. Nominal fees and extra time are involved. Please contact us at info@jinpanbio.com for details about irradiation costs and additional lead-time.A nutritionist can assist you in determining if a formula is suitable for irradiation. Irradiation will lead to selective vitamin loss, and it is our practice to increase the inclusion rate of certain vitamin mixes to help ensure that the final diet contains sufficient vitamins. Irradiated diets are double-bagged. Vacuum packaging may be helpful in reducing irradiation-induced peroxide formation in high fat diets.25. How can I order a diet supplied to someone by Envigo, and subsequently noted in a research article?Some diet formulas are fairly common or generic, and probably are not considered confidential by those who use them, especially when authors provide a product number. Formulas might be difficult to trace without a product number, and then must be discussed with a nutritionist. We will review each formula for history and confidentiality.Provide us with at the very least a description, preferably the complete formula, and we’ll give you an assessment of our ability to make that formula.There are limitations for pelleting diets. The level and type of fat, the carbohydrate composition, and the interaction of fat and carbohydrate will impact our ability to pellet a diet. Consult a nutritionist at info@jinpanbio.com for more information about specific formulas.\"Vitamin-Free” Test Casein is an alcohol-extracted casein prepared from regular casein, and typically has 90-91% protein (%N x 6.38), 0.1% fat, and four-six % moisture. The alcohol extraction reduces fat, fat soluble vitamins, and some of the B vitamins. This protein source is most appropriately used in vitamin deficient diets, and when researchers want to minimize \"background fat” in a diet. We have prepared this specialty ingredient for many years, and continue to supply it to many labs. We will develop special pricing on request for large quantities. Advance notice is recommended for orders of 1,000 Kg or more. If you need this ingredient, consider Envigo as your preferred source.Yes. Some of the same high-quality ingredients used to produce custom research diets can also be supplied to those who prepare their own diets. See diet ingredients for more information.When citing Teklad diets, include a description, and a product number — standard grain based diets are typically four numbers while custom diets usually start with \"TD” followed by five or six numbers. Use the following examples as a guide:\"Rats were maintained on minimal phytoestrogen diet 2016 Teklad Global 16% Protein Rodent Diet, Envigo, Madison, Wisconsin USA, www.amrescoinc.cn”\"Obesity was induced by feeding Teklad high fat diet TD.06414 with 60% of kcal from fat, primarily lard, Envigo, Madison, Wisconsin USA, www.amrescoinc.cn”\"Mice were fed Teklad vitamin D deficient diet TD.89123, Envigo, Madison Wisconsin USA, www.amrescoinc.cnEach diet has a unique product number that will allow others to quickly and easily obtain information about the diet used in your studies by contacting info@jinpanbio.com31. Are compounds (such as doxycycline, fenbendazole, customer supplied test compounds, etc) considered pharmaceutical grade once added to an animal diet?No. According to the NIH OACU Guidelines for Use of Non-Pharmaceutical-Grade Chemicals/Compounds in Laboratory Animals (2008), the vehicle used to facilitate administration of a compound is as important of a consideration as the active compound in the preparation. Diet as a vehicle, either whole or as the sum of its parts, would not meet the standard for pharmaceutical grade as defined by this document.You may have been asked this question by your IACUC due to a passage in the 8thedition of the Guide for the Care and Use of Laboratory Animals (2011) stating that pharmaceutical-grade chemicals and other substances should be used, when available, for all animal-related procedures (page 31). In general, deviations from \"Must” or \"Should” statements within the Guide require justification and approval by your institutional IACUC.Alternative dosing techniques (gavage, injection) can introduce stress from handling and increase the risk for potential injury. Stress can affect animal well-being as well as scientific parameters through modifications in behavior and physiology. Dosing via diet is an established method for delivering test compounds to animals that is non-invasive, reducing stress and potential injury from handling. Therefore, use of non-pharmaceutical grade compounds as a delivery method is justified, as it is advantageous for both animal welfare and experimental design.Further reading:Guide for the Care and Use of Laboratory Animals: 8th Edition (2011). National Research Council Committee for the Update of the Guide for the Care and Use of Laboratory Animals.Guidelines for the Use of Non-Pharmaceutical-Grade Chemicals/Compounds in Laboratory Animals. (2008). Animal Research Advisory Committee, Office of Animal Care and Use, NIH.Laboratory routines cause animal stress. (2004). Balcombe, J.P., Barnard, N.D., and Sandusky, C. Contemp Top Lab Anim Sci 43, 42-51.