We have three different anti-mGluR antibodies, each of which binds to a specific peptide sequence(s) present in different sets of mGluR gene family members. The ER2/3 antibody represents sequences found in both mGluR2 and mGluR3. (Note that this product cannot distinguish between these two receptors.) It comprises two antipeptide antibodies generated against overlapping sequences specific to the mGluR2 and mGluR3 gene products but not found in other mGluR gene family members. This antibody has been validated for immunohistochemistry and immunocytochemistry using mouse brain sections and cultured neuroblastoma cells as well as in rat brain sections.Volume: 1000 µLConcentration: 200 µg/mLClonality: PolyclonalHost Species: ChickenSpecies Reactivity:Human, Mouse, RatApplications: ICC, IHCProtein Name / Synonyms: Metabotropic glutamate receptor 2 (mGluR2), Metabotropic glutamate receptor 3 (mGluR3)Target Description: The metabotropic glutamate receptors (mGluRs) represent a gene family of G-protein-coupled receptors, all of which bind the amino acid glutamate (the major excitatory neurotransmitter of the nervous system) but differ in their primary amino acid structure, their pharmacology, and their distribution in the peripheral and central nervous systems. In general, mGluR1 and mGluR5 receptors are post-synaptic and mGluR2 and mGluR3 receptors are pre-synaptic.Gene ID: GRM2 GPRC1B MGLUR2 (mGluR2) and GRM3 GPRC1C MGLUR3 (mGluR3)Antibody Registry ID (RRID): AB_2313542Physical State: LiquidProduction Notes: Chickens were immunized with two synthetic peptide / keyhole limpet hemocyanin (KLH) conjugates. These synthetic peptides corresponded to unique sequences within the metabotropic glutamate receptor type 2 and type 3 gene products, but was shared between the human (Q14416.2, Q14832.2 NCBI) and mouse (Q14B12.2, Q9QYS2.1, NCBI) sequences. After repeated injections, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, the concentrations of the eluates adjusted to 200 µg/mL, and the preparation was filter-sterilized.Validation and Application NotesIHC Dilution Range: 1:1000-1:2000Quality ControlThis anti-peptide antibody preparation was analyzed by immunohisto­chemistry (at a dilution of 1:2000) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution, Aves Labs Cat.# F-1005) as the secondary reagent.StorageStore at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least 12 months (provided they remain sterile). Do not freeze these antibodies unless you want to store them for longer periods of time. Note, however, that each time an antibody preparation is frozen, about half of its binding activity is lost.NOTEAves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.↑ back to top

神经元标志蛋白抗体

该系列产品主要用于神经元细胞的各亚细胞结构研究，可与现有的小鼠/兔抗体进行免疫双标，反应性包括人、小鼠等多个哺乳类动物。在保证抗体特异性的前提下，部分产品可分为抗不同的氨基酸片段。该系列产品包括抗APP3/APP345/APP4/APP5/ABN/TUJ/CAT/ DCX/ER1/ER2/ER3/ER5/GAD/GAP43/MAP/NET/ NUN/NSE/ NFH / NFL / NFM / PER/ PRN / PAP/ STG / TAU / TYH的抗体。除单独的抗体提供，我们还可同时提供1/3种任意抗体组合及相应二抗的试剂盒，以更优惠的价格及便捷性以满足研究人员的不同需要。