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Anaspec/Angiotensin I, human/5 mg/AS-20627
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产品说明
Product NameAngiotensin I, humanDRVYIHPFHL Size5 mg Catalog #AS-20627 US$$26 Purity% Peak Area By HPLC ≥ 95% DescriptionThis human Angiotensin I (Ang I) sequence also corresponds to horse, sheep, pig, and rat Ang I. Ang I is cleaved to Ang II by the angiotensin-converting enzyme (ACE). There is also evidence for non-angiotensin-converting enzyme-dependent conversion of Ang I to Ang II. Human chymase efficiently converts the 10-mer Ang I to the 8-mer hormone Ang II by splitting the Phe8-His9 bond in Ang I. Detailed InformationDatasheetMaterial Safety Data Sheets (MSDS) Storage-20°C ReferencesRef: Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Olson, S. et al. Am. J. Physiol. Lung. Cell Mol. Physiol. 287, L559 (2004); Sanker, S. et al. J. Biol. Chem. 272, 2963 (1997). Molecular Weight1296.5 Sequence(One-Letter Code)DRVYIHPFHLSequence(Three-Letter Code)H - Asp - Arg - Val - Tyr - Ile - His - Pro - Phe - His - Leu - OHProduct CitationsBasile, F. et al. (2011). Rapid online nonenzymatic protein digestion combining microwave heating acid hydrolysis and electrochemical oxidation. Anal Chem 83, 359.Keppel, T. et al. (2009). The use of acetone as a substitute for acetonitrile in analysis of peptides by liquid chromatography/electrospray ionization mass spectrometry. Rapid Comm Mass Spectrom 24, 6.Rauniyar, N. et al. (2009). Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation. Anal Chem 81, 782.

Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中,包括真菌,昆虫,两栖动物和人类中,已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素,杀真菌,溶血,杀病毒和杀肿瘤活性。基于它们的结构特性,这些抗菌肽可分为三类:螺旋状肽,含有一个至几个二硫键的肽以及富含某些氨基酸(例如脯氨酸或色氨酸)的肽。这些肽大多数具有一些共同的特征,例如它们的低分子量(2-5 kDa),存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制,但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素,其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A,B和D是紧密的同源物,由天蚕素蛾的35中发现的35-39个残基组成。

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