首页 > Anaspec > Anaspec/Beta - Amyloid (1 - 40) Binding Peptide, Biotin - labeled/1 mg/AS-62427

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Anaspec/Beta - Amyloid (1 - 40) Binding Peptide, Biotin - labeled/1 mg/AS-62427

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Product NameBeta - Amyloid (1 - 40) Binding Peptide, Biotin - labeledBiotin - DWGKGGRWRLWPGASGKTEA Size1 mg Catalog #AS-62427 US$$197 Purity% Peak Area By HPLC ≥ 95% DescriptionThis 20 amino acid peptide binds to the amyloid form of beta-Amyloid (1-40) but not to monomeric beta-Amyloid (1-40). This sequence represents new potential carrier molecules to deliver medicines to amyloid plaques in AD patients and to image plaques in AD brains. The ability to directly target reagents to the amyloid form of the beta-Amyloid peptide may allow the delivery of neuroprotective agents to make amyloid plaques less toxic, the delivery of amyloid-destroying molecules to eliminate plaques, or the delivery of reagents to prevent amyloid plaque formation. This sequence is biotinylated on the N-terminus. Detailed InformationMaterial Safety Data Sheets (MSDS) Storage-20°C ReferencesKang, C. et al. Neurobiol. Dis. 14, 146 (2003). Molecular Weight2441.8 Sequence(One-Letter Code)Biotin-DWGKGGRWRLWPGASGKTEASequence(Three-Letter Code)Biotin - Asp - Trp - Gly - Lys - Gly - Gly - Arg - Trp - Arg - Leu - Trp - Pro - Gly - Ala - Ser - Gly - Lys - Thr - Glu - Ala - OHProduct CitationsInaba, S. et al. (2005). Specific binding of amyloid‐β‐protein to IMR‐32 neuroblastoma cell membrane J. Peptide Res. 65, 485. https://doi.org/10.1111/j.1399-3011.2005.00250.x Qingyou, Li et al. (2004). Overcoming Antigen Masking of Anti-Amyloidbeta Antibodies Reveals Breaking of B Cell Tolerance by Virus-Like Particles in Amyloidbeta Immunized Amyloid Precursor Protein Transgenic Mice

Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。