Lawrence A. Hunt, University of Louisville School of Medicine, Louisville, KY, USASearch for more papers by this author Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Classical live-attenuated vaccines were developed several decades ago for two clinically important human herpesviruses, varicella-zoster virus and human cytomegalovirus. The varicella vaccine has been licensed for immunization of normal children in Japan, Korea, and the United States for a number of years. In contrast, live-attenuated cytomegalovirus has only been tested in a limited number of studies of organ transplant recipients and healthy adult volunteers, and has not yet been considered for licensure. A number of experimental cytomegalovirus vaccines have been developed using molecular biology and recombinant DNA technology, because of theoretical concerns about the long-term safety and effectiveness of the currently available live cytomegalovirus vaccines. Some of the same techniques are also being applied to varicella-zoster virus to develop improved vaccines that could supplement or replace the current varicella vaccine or provide protection against viral reactivation and zoster. The major emphasis of high-technology vaccine development has been on the viral glycoproteins because they are the targets of neutralizing antibody, and includes both recombinant protein subunit vaccines and live-recombinant virus vaccines. Other virion and nonstructural viral proteins are also being considered as immunogens for cytotoxic T-cell responses. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online Library account. Can\'t sign in? Forgot your username? Enter your email address below and we will send you your username If the address matches an existing account you will receive an email with instructions to retrieve your username