产品说明
DescriptionRabbit Fibrinogen Polyclonal Antibody – HRP ConjugatedAffinity’s Rabbit Fibrinogen Polyclonal Antibody – HRP Conjugated is the base level of our horseradish peroxidase conjugated Rabbit Fibrinogen antibodies. The purity of IgG is typically 90% and is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v). The titre is essentially the same as the starting antiserum and each vial typically contains the amount of IgG recovered from one milliliter of antiserum however this IgG has been conjugated with Horseradish Peroxidase as an enzyme reporter. This Rabbit Fibrinogen Polyclonal Antibody – HRP Conjugated is generally intended for use as labeled primary antibodies in applications such as immunoassay and immunoblotting.Product Code: SARFG-HRPRetail Product Size:0.2mg vialHost Animal: Sheep Anti-Rabbit Fibrinogen Polyclonal Antibody – HRP ConjugatedSpecies Cross Reactivity: View ChartProduct Datasheet: Fibrinogen Polyclonal Antibody, HRP conjugated anti-rabbit Sheep IgGDescription of FibrinogenMost of the fibrinogen in the circulation consists of 2 copies of each chain (Aα2, Bβ2, γA2), but in normal plasma approximately 10% of the fibrinogen molecules contain one γA chain and one variant γ chain (termed γ′), in which the c-terminal AGDV residues are replaced with the amino acid sequence VRPEHPAETEYDSLYPEDDL. This variant fibrinogen is commonly referred to as fibrinogen gamma prime (γA/γ′) but has also been called fibrinogen 2 or peak 2 fibrinogen because it elutes separately from fibrinogen 1 (γA2) by ion exchange chromatography. Residues 414-427 of the γ′ chain of fibrin gamma prime (contain a high-affinity binding site for exosite II of thrombin, which allows the active site of bound thrombin to remain available to interact with substrates while demonstrating resistance to heparin mediated inhibition by antithrombin1-4.References and Reviews1. Hantgan RR, Francis CW, Marder VJ; Fibrinogen Structure and Physiology; in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp 277-300, J.B. Lippincott Co., Philadelphia PA, USA, 1994.2. Binnie CG, Lord ST; The Fibrinogen Sequences that Interact with Thrombin; Blood 81, pp 3186-3192, 1993.3. Pospisil CH, Stafford AR, Fredenburgh JC, Weitz JI; Evidence that both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin; JBC 278, pp 21584-21591, 2003.4. Medved L, Weisel JW; Recommendations for Nomenclature on Fibrinogen and Fibrin; JTH 7, pp 355-359, 2009.
Affinity Biologics生产针对凝血,止血和纤维蛋白溶解相关蛋白的全系列多克隆抗体。我们的多克隆抗体家族有多种形式。完整或纯化的IgG,亲和纯化的IgG,辣根过氧化物酶偶联,异硫氰酸荧光素(FITC)偶联和生物素偶联。所有与凝血,止血和纤维蛋白溶解相关蛋白以及缺乏因子的血浆产品有关的Affinity Biologicals多克隆抗体均在内部采购,并根据ISO13485医疗设备质量保证标准生产。
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