产品说明
DescriptionMurine Fibrinogen Paired Antibody SetAffinity’s Murine Fibrinogen Paired Antibody Set consists of matched capture and detecting antibodies only that have been titrated and optimized for use in sandwich style ELISA assays. The product as provided contains sufficient capture and detecting antibodies for four full 96-well microplates and contains a detailed protocol sheet containing directions for use, recipes for solutions and sources for additional materials required. This Murine Fibrinogen Paired Antibody Set is intended to facilitate the end user in establishing an “in-house” immunoassay for research purposes only and must not be used for diagnostic applications. Assay validation is the responsibility of the end user.Product Code: MFG-EIASupplied Materials: 1. Capture Antibody (MFG-EIA-C): One yellow-capped vial containing 0.4 ml of polyclonal affinity purified anti-Fibrinogen antibody for coating plates.2. Detecting Antibody (MFG-EIA-D): One red-capped tube containing 0.4 ml of peroxidase conjugated affinity-purified polyclonal anti-Fibrinogen antibody for detection of captured Fibrinogen.Related Products: VisuLize Buffer PakSpecies Cross Reactivity: View ChartProduct Datasheet: Murine Fibrinogen Antigen Matched Pair Antibody Set for ELISA - MFG-EIADescription of FibrinogenMost of the fibrinogen in the circulation consists of 2 copies of each chain (Aα2, Bβ2, γA2), but in normal plasma approximately 10% of the fibrinogen molecules contain one γA chain and one variant γ chain (termed γ′), in which the c-terminal AGDV residues are replaced with the amino acid sequence VRPEHPAETEYDSLYPEDDL. This variant fibrinogen is commonly referred to as fibrinogen gamma prime (γA/γ′) but has also been called fibrinogen 2 or peak 2 fibrinogen because it elutes separately from fibrinogen 1 (γA2) by ion exchange chromatography. Residues 414-427 of the γ′ chain of fibrin gamma prime (contain a high-affinity binding site for exosite II of thrombin, which allows the active site of bound thrombin to remain available to interact with substrates while demonstrating resistance to heparin mediated inhibition by antithrombin1-4.References and ReviewsHantgan RR, Francis CW, Marder VJ; Fibrinogen Structure and Physiology; in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp 277-300, J.B. Lippincott Co., Philadelphia PA, USA, 1994.Binnie CG, Lord ST; The Fibrinogen Sequences that Interact with Thrombin; Blood 81, pp 3186-3192, 1993.Pospisil CH, Stafford AR, Fredenburgh JC, Weitz JI; Evidence that both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin; JBC 278, pp 21584-21591, 2003.Medved L, Weisel JW; Recommendations for Nomenclature on Fibrinogen and Fibrin; JTH 7, pp 355-359, 2009.
Affinity Biologics生产针对凝血,止血和纤维蛋白溶解相关蛋白的全系列多克隆抗体。我们的多克隆抗体家族有多种形式。完整或纯化的IgG,亲和纯化的IgG,辣根过氧化物酶偶联,异硫氰酸荧光素(FITC)偶联和生物素偶联。所有与凝血,止血和纤维蛋白溶解相关蛋白以及缺乏因子的血浆产品有关的Affinity Biologicals多克隆抗体均在内部采购,并根据ISO13485医疗设备质量保证标准生产。
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