产品说明
DescriptionFactor IX Polyclonal Antibody – SheepAffinity’s Factor IX Polyclonal Antibody – Sheep is the base level of our Factor IX antibody family. The purity of IgG is typically 90% and is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v). The titre is essentially the same as the starting antiserum and each vial typically contains the amount of IgG recovered from one milliliter of antiserum. This Factor IX Polyclonal Antibody – Sheep is generally intended for use in applications such as immuno-precipitation, immuno-electrophoresis, immuno-depletion and activity neutralization assays.Product Code: SAFIX-IGRetail Product Size: 10mg vialHost Animal: Sheep Anti-Human Factor IX Polyclonal AntibodySpecies Cross Reactivity: View ChartProduct Datasheet: Factor IX F9 Polyclonal Antibody, purified anti-human sheep IgGDescription of Factor IX (FIX)Factor IX (FIX, Christmas Factor) is a vitamin K-dependent glycoprotein produced in the liver. Plasma concentration of FIX is normally around 5 μg/ml (87 nM) in plasma. The biological importance of FIX is demonstrated in Haemophilia B (Christmas disease), an X-linked congenital bleeding disease resulting from a quantitative (low activity and low antigen) or qualitative (low activity, normal antigen) defect in FIX function.In its proenzyme or zymogen form FIX is a single chain molecule of 55,000 daltons. It contains two EGF-like domains and an amino-terminal domain containing 12 γ-carboxy-glutamic acid (Gla) residues. These Gla residues allow FIX to bind divalent metal ions and participate in calcium-dependent binding interactions. The activation of F.IX occurs by limited proteolysis in the presence of calcium by activated factor XI (FXIa) and/or by a complex of VIIa/tissue factor/phospholipid and activated Factor X between residues Arg146-Ala147 and between Arg180-Val181. The terminal activated product in either case is FIXaβ, a two-chain enzyme consisting of a heavy chain (28,000 daltons), a light chain (18,000 daltons) and an activation peptide product of 11,000 daltons. FIX can also be cleaved into inactive products by thrombin and by elastase.The activity of FIXaβ in plasma is inhibited by antithrombin and this inhibition is accelerated 1000-fold in the presence of optimal concentrations of heparin 1-3.References and ReviewsLawson, JH, Mann KG; Cooperative Activation of Human F.IX by the Human Extrinsic Pathway of Coagulation; JBC 266 pp11317-11327, 10991.Enfield DL, Thompson AR; Cleavage and Activation of Factor IX by Serine Proteases; Blood 64, pp 821-831, 1984.Limentani SA, Furie BC, Furie B, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 94-108, J.B. Lippincott Co., Philadelphia PA, USA, 1994
Affinity Biologics生产针对凝血,止血和纤维蛋白溶解相关蛋白的全系列多克隆抗体。我们的多克隆抗体家族有多种形式。完整或纯化的IgG,亲和纯化的IgG,辣根过氧化物酶偶联,异硫氰酸荧光素(FITC)偶联和生物素偶联。所有与凝血,止血和纤维蛋白溶解相关蛋白以及缺乏因子的血浆产品有关的Affinity Biologicals多克隆抗体均在内部采购,并根据ISO13485医疗设备质量保证标准生产。
新品排行榜
1
affinity biologicals/Normal Refe...
2
affinity biologicals/Factor IX P...
3
affinity biologicals/Factor VII ...
4
affinity biologicals/Protein S P...
5
affinity biologicals/Normal Refe...
6
affinity biologicals/Canine Fact...
7
affinity biologicals/Hemostasis ...
8
affinity biologicals/Abnormal He...
9
affinity biologicals/Abnormal Re...
10
affinity biologicals/Frozen Fact...
文章排行榜
1
(PDF) The Affinity Grid: A Pre-fabricated EM Grid for...
2
...Claudin 1 (Tyr210) Antibody - AF8256 - affinity_biosciences
3
Affinity Purified anti-human CD133 / AC133 (Prominin I)
4
...affinity purified)_价格-厂家-供应商_Agrisera AB
5
Rat Fas/TNFRSF6/CD95 Biotinylated Affinity Purified PAb (50 UG)
6
Mouse TWEAK/TNFSF12 Biotinylated Affinity Purified PAb (50 UG)
7
CD64 / FCGR1A Antibody (Antigen Affinity Purified)
8
Anti-DYKDDDDK(flag) G1 Affinity Resin \
9
Human GRAIL/RNF128 Affinity Purified Polyclonal Ab (100 UG)
10
...anti-TFEB Antibody, Affinity Purified,100 ul (1 mg/ml)_价格...