SpecificationsSpecificationsAdditional InformationCatalog #54-043SpeciesCanineRegulatory StatusResearch Use Only. Not for Use in Diagnostic Procedures.Product DistributionAvailable in North America OnlyRange4 - 400 pg/mLSensitivity0.56 pg/mLSizes96 WellsSample TypesCell Culture, Plasma, Serum, Tissue Culture, UrineIncubation Time3 hr .inchour { display:none; } Incubation Time3 hr 10 minSample Size10µLInstructions for UseClick here to viewSafety Data SheetClick here to viewAdditional InformationAdditional InformationNGAL (neutrophil gelatinase-associated lipocalin) belongs to the lipocalin family of proteins. These are small secreted proteins characterized by their ability i) to bind small hydrophobic molecules in a structurally conserved pocket formed by β-pleated sheet, ii) to bind to specific cell-surface receptors, and iii) to form macromolecular complexes. NGAL has many synonyms: perhaps the most widely used is lipocalin2 (LCN 2); more recently the name siderocalin has been used to express NGAL’s ability to bind bacterial siderophores. As NGAL was first reported as oncogene 24p3 in the mouse, this name is still occasionally used to identify NGAL in other species.Because dog NGAL has not yet been isolated and no antibodies or immunochemical detection methods have hitherto been developed to detect or measure it, there are no published data on the physiological or pathological functions of this protein in the dog. However, it is likely that some features of the biosynthesis, location and release of dog NGAL will be similar to those of its homologues in other species. The present kit has in fact been developed to extend NGAL research and the use of NGAL as a marker molecule, especially for kidney injury, to the dog. In the following, some pathophysiological features of NGAL in other mammalian species will be mentioned, because similar features may be observed in the dog.Like other mammalian NGALs, dog NGAL may in certain situations be co-expressed and form complexes with matrix metalloproteinase-9 (MMP-9). Dog NGAL may also prove to form homodimers and higher oligomers with itself. As dog NGAL, unlike its human homologue but like all other mammalian NGALs known, does not possess a third cysteinyl residue capable of forming an intermolecular disulfide bridge, any complex formation detected will probably depend on non-covalent forces, at least initially.Related ContentRelated ContentEarly Detection of Diabetic Kidney Disease with BiomarkersFeatured ContentIntroduction Over one third of diabetics will develop diabetic kidney disease (DKD) in their lifetime1. Despite the large amount of diabetics suffering from DKD, current methods for measuring and tracking kidney function may not be specific enough for diabetic systems2,3. […]View MoreProduct ReviewsProduct ReviewsWrite a ReviewOnly registered users can write reviews. Please, log in or registerRelated ProductsRelated ProductsNGAL ELISA (Lipocalin)Add to CartRequest a QuoteQuote RequestProduct: NGAL ELISA (Lipocalin)Catalog#: 54-036Qty:Comments:First Name:Last Name:Company:Email:Phone:Billing AddressAddress:City:State:Country:United StatesCanadaGermanyZipcode:Telephone:Shipping AddressSame as Billing AddressAddress:City:State:Country:United StatesCanadaGermanyZipcode:Telephone:Submit a quoteCatalog Number54-036Sensitivity: 4 pg/mLRange: 10-1000 pg/mLSample Types: Cell Culture, Plasma, Serum, Tissue Culture, UrineSample Size(s):10 µL Add to Compare Add to WishlistPorcine NGAL ELISAAdd to CartRequest a QuoteQuote RequestProduct: Porcine NGAL ELISACatalog#: 54-044Qty:Comments:First Name:Last Name:Company:Email:Phone:Billing AddressAddress:City:State:Country:United StatesCanadaGermanyZipcode:Telephone:Shipping AddressSame as Billing AddressAddress:City:State:Country:United StatesCanadaGermanyZipcode:Telephone:Submit a quoteCatalog Number54-044Sensitivity: 1.0 pg/mLRange: 10 - 400 pg/mLSample Types: Cell Culture, Plasma, Serum, Tissue Culture, UrineSample Size(s):10 µL Add to Compare Add to Wishlist