Adalimumab Biosimilar – Research Grade – Fc-Silenced [ICH1177]$1,680.00Size:Choose an option1mgEndotoxin Level:Choose an optionLowClearAdalimumab Biosimilar – Research Grade – Fc-Silenced [ICH1177]Adalimumab Biosimilar - Research Grade - Fc-Silenced [ICH1177] quantity— OR —Add to cartSKU: ICH1177-FCCategories: anti-human, Biosimilar Antibodies, Fc-Silenced, Low EndotoxinBrowseAntibodiesBiosimilar AntibodiesIsotype ControlsLow EndotoxinUltra Low EndotoxinAntibody Labeling KitsApplicationsBlockingCODEXCyTOFDot BlotELISAELISpotFlow CytometryFlow Cytometry (intracellular)Functional AssaysIHC (Frozen)IHC (Paraffin)ImmunoCytoChemistryImmunofluorescenceImmunoprecipitationIn Situ HybridizationIn Vivo DepletionIP-Mass SpectrometryNeutralizationWestern BlotConjugatedAPCBiotinDyLight 488DyLight 550DyLight 594DyLight 633DyLight 650DyLight 680DyLight 755DyLight 800FITCPEPE/Cy7PerCPDetergentsFc-SilencedGel StainInhibitorsRecombinant ProteinsSpecies Reactivityanti-bovineanti-chickenanti-humananti-mouseanti-ratMonkeyDescriptionAdditional informationReviews (0)Bulk Adalimumab Biosimilar – Research Grade – Fc-SilencedProduct Benefits:This biosimilar is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.Target:TNF alphaClone:D2E7Isotype:Human IgG1 κHost:HumanSpecies Reactivity:HumanSpecificity:This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Adalimumab. Clone D2E7 binds to soluble TNF- α, but not to TNF- β (lymphotoxin).Antigen Distribution:TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, B cells, NK cells, LAK cells.Background:Adalimumab is a research-grade monoclonal antibody that works by inactivating tumor necrosis factor-alpha (TNF-α). TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α inactivation has proven to be important in downregulating the inflammatory reactions associated with autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, moderate to severe chronic psoriasis, and juvenile idiopathic arthritis. Adalimumab blocks the interaction with the p55 and p75 cell surface TNF receptors thus, neutralizing the biological function of TNF. Anti-Human TNF alpha (Adalimumab) utilizes the same variable regions from the therapeutic antibody Adalimumab making it ideal for research projects.Immunogen:Human TNF alphaConcentration:≥ 2.0 mg/mlFormulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 – 7.4, 150 mM NaCl with no carrier protein, potassium, calcium or preservatives added.Purity:>99% by SDS-PAGE and HPLCEndotoxin:<0.5 EU/mg as determined by the LAL methodStorage:This biosimilar is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.Applications:Blocking, ELISA, Functional Assays, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, NeutralisationApplication Notes:Each investigator should determine their own optimal working dilution for specific applications.Isotype Control:Products are for research use only. Not for use in diagnostic or therapeutic procedures.Size:1mgEndotoxin Level:LowReviewsThere are no reviews yet.Be the first to review “Adalimumab Biosimilar – Research Grade – Fc-Silenced [ICH1177]” Cancel replyYour rating*Rate…PerfectGoodAverageNot that badVery poorYour review*Name*Email* Save my name, email, and website in this browser for the next time I comment. Related products+Quick Viewanti-mouseAnti-CTLA-4 In Vivo Antibody – Low Endotoxin (9H10) [ICH1084]$320.00 – $2,378.00+Quick ViewIsotype ControlsMouse IgG3 Isotype Control for In Vivo – Low Endotoxin (MG3-35) [ICH2249]$320.00 – $2,378.00+Quick ViewIsotype ControlsMouse IgM Isotype Control for In Vivo – Low Endotoxin [ICH2252]$320.00 – $2,378.00+Quick Viewanti-mouseAnti-CD80 In Vivo Antibody – Low Endotoxin (16-10A1) [ICH1037]$320.00 – $2,378.00