BiologicalActivity
PotentandselectiveinhibitoroftheTGF-βtypeIreceptor/ALK5(IC50valuesare4and23nMforTGF-βtypeIreceptorautophosphorylationandbindingrespectively).SelectiveforTGF-βtypeIreceptoroverarangeofkinases,includingp38MAPK,JNK1andGSK3(IC50>16μM).Enhancestheefficiencyofcellularreprogramming;replacesSox2byinducingNanogexpression.
CompoundLibraries
RepSoxisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 287.32 |
| Formula | C17H13N5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 446859-33-2 |
| PubChemID | 449054 |
| InChIKey | LBPKYPYHDKKRFS-UHFFFAOYSA-N |
| Smiles | CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.73 | 100 | |
| ethanol | 14.37 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight287.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.48mL | 17.4mL | 34.8mL |
| 5mM | 0.7mL | 3.48mL | 6.96mL |
| 10mM | 0.35mL | 1.74mL | 3.48mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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