Tocris产品目录价格 Tocris小分子,Tocris/SB 431542/1614/10/10 mg,氨基酸,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/SB 431542/1614/10/10 mg

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Tocris Bioscience

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1614/10

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4000-520-616

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Description:Potent,selectiveinhibitorofTGF-βRI,ALK4andALK7

ChemicalName:4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinhibitorofthetransforminggrowthfactor-β(TGF-β)typeIreceptoractivinreceptor-likekinaseALK5(IC₅₀=94nM),anditsrelativesALK4andALK7.SuppressesTGF-β-inducedproliferationofhumanosteosarcomacells.Stimulatesproliferation,differentiationandsheetformationofESC-derivedendothelialcells.InhibitsTGF-β-inducedEMT,migration,invasionandVEGFsecretioninseveralhumancancercelllines.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

SB431542isalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	384.39
Formula	C₂₂H₁₆N₄O₃
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	301836-41-9
PubChemID	4521392
InChIKey	FHYUGAJXYORMHI-UHFFFAOYSA-N
Smiles	NC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=N1)C1=CC2=C(OCO2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	38.44	100
	ethanol	3.84	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight384.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.6mL	13.01mL	26.02mL
5mM	0.52mL	2.6mL	5.2mL
10mM	0.26mL	1.3mL	2.6mL
50mM	0.05mL	0.26mL	0.52mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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