Tocris产品目录价格 Tocris GPCR ligands,Tocris/SB 505124/3263/50/50 mg,氨基酸,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/SB 505124/3263/50/50 mg

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Tocris Bioscience

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3263/50

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4000-520-616

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Description:SelectiveinhibitorofTGF-βRI,ALK4andALK7

ChemicalName:2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveinhibitoroftransforminggrowthfactor-βtypeIreceptor(ALK5),ALK4andALK7(IC₅₀valuesare47and129nMforALK5andALK4respectively).SelectivelyinhibitssignalingfromTGF-βandactivin;doesnotinhibitotherALKfamilymembers.

TechnicalData

M.Wt	335.4
Formula	C₂₀H₂₁N₃O₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	694433-59-5
PubChemID	9858940
InChIKey	WGZOTBUYUFBEPZ-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=NC(C2=CC(OCO4)=C4C=C2)=C(C3=NC(C)=CC=C3)N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	33.54	100
	DMSO	33.54	100
	ethanol	8.38	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight335.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.98mL	14.91mL	29.82mL
5mM	0.6mL	2.98mL	5.96mL
10mM	0.3mL	1.49mL	2.98mL
50mM	0.06mL	0.3mL	0.6mL

ProductDatasheets

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