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Tocris/SB 525334/3211/50/50 mg

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Tocris Bioscience

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3211/50

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4000-520-616

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Description:SelectiveinhibitorofTGF-βRI

ChemicalName:6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveinhibitoroftransforminggrowthfactor-βreceptorI(ALK5,TGF-βRI)(IC₅₀=14.3nM).InhibitsTGF-β1-inducedsmad2/3nuclearlocalizationandTGF-βRI-inducedmRNAexpressioninkidneycells.Attenuatesbleomycin-inducedpulmonaryfibrosis.

LicensingInformation

SoldwiththepermissionofGlaxoSmithKline

CompoundLibraries

SB525334isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	343.42
Formula	C₂₁H₂₁N₅
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	356559-20-1
PubChemID	9967941
InChIKey	DKPQHFZUICCZHF-UHFFFAOYSA-N
Smiles	CC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	34.34	100
	DMSO	34.34	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight343.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.91mL	14.56mL	29.12mL
5mM	0.58mL	2.91mL	5.82mL
10mM	0.29mL	1.46mL	2.91mL
50mM	0.06mL	0.29mL	0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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