BiologicalActivity
SelectiveSmad3inhibitor;attenuatesTGF-β1-dependentSmad3phosphorylationandDNAbinding.HasnoeffectonSmad2,p38MAPK,ERKorPI3-kinasesignaling.InhibitsTGF-β1-inducedmyofibroblastdifferentiationofdermalfibroblasts.AlsoinhibitsTGF-β2-inducedendothelialcelldifferentiationiniPSCs.
CompoundLibraries
SIS3isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 489.99 |
| Formula | C28H27N3O3.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 521984-48-5 |
| PubChemID | 16079005 |
| InChIKey | CDKIEBFIMCSCBB-CALJPSDSSA-N |
| Smiles | O=C(N4CCC(C=C(OC)C(OC)=C5)=C5C4)/C=C/C2=C(C3=CC=CC=C3)N(C)C1=NC=CC=C12.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight489.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.04mL | 10.2mL | 20.41mL |
| 5mM | 0.41mL | 2.04mL | 4.08mL |
| 10mM | 0.2mL | 1.02mL | 2.04mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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