BiologicalActivity
PotentandselectiveinhibitoroftypeIbonemorphogenicprotein(BMP)receptorALK2(IC50=24nM).ShowspreferenceforALK1andALK2overALK3and164-foldselectivityforBMP6inhibition(IC50=100nM)overTGF-β1.ExhibitsimprovedkinomeselectivityoverK02288(Cat.No.4986)andlowcytotoxicity.
LicensingInformation
SoldforresearchpurposesunderexclusiveagreementfromTheBrighamandWomen"sHospitalInc.USpatent14/776,302
TechnicalData
| M.Wt | 419.52 |
| Formula | C25H29N3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1627503-67-6 |
| PubChemID | 91754554 |
| InChIKey | BHUXVRVMMYAXKN-UHFFFAOYSA-N |
| Smiles | COC1=CC(C2=C(N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)C)=CC(OC)=C1OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.95 | 100 | |
| ethanol | 41.95 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight419.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.38mL | 11.92mL | 23.84mL |
| 5mM | 0.48mL | 2.38mL | 4.77mL |
| 10mM | 0.24mL | 1.19mL | 2.38mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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