BiologicalActivity
Antiviralagent,activeagainstherpessimplexvirusesHSV-1andHSV-2(EC50valuesare0.85and0.86μMrespectively).InterfereswithviralDNApolymerizationthroughcompetitiveinhibitionwithguanosinetriphosphate.InducesapoptosisincellstransfectedwithHSV-TK(suicidalgenetherapy).
CompoundLibraries
AcyclovirisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 225.21 |
| Formula | C8H11N5O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 59277-89-3 |
| PubChemID | 2022 |
| InChIKey | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| Smiles | NC1=NC(=O)C2=C(N1)N(COCCO)C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 11.26 | 50 | |
| DMSO | 4.5 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight225.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.44mL | 22.2mL | 44.4mL |
| 5mM | 0.89mL | 4.44mL | 8.88mL |
| 10mM | 0.44mL | 2.22mL | 4.44mL |
| 50mM | 0.09mL | 0.44mL | 0.89mL |
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