商品信息
联系客服
郑重提醒:
无质量问题不接受退换货,下单前请仔细核对信息。
下单后请及时联系客服核对商品价格,订单生效后再付款。
Tocris/AZD 2461/6060/50/50 mg
免费咨询热线
4000-520-616
Description:PotentPARPinhibitor;orallybioavailable
ChemicalName:4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentPARPinhibitor(IC50valuesare2,5and200nMforPARP2,PARP1andPARP3,respectively).ExhibitsanticancereffectsinBRCA1mutant,butnotwild-typebreastcancercelllinesinvitro.Inhibitsgrowthofolaparib-resistantmammarytumorsinamousemodelandisapoorsubstratefortheP-gptransporter.Orallybioavailable.
TechnicalData
M.Wt | 395.43 |
Formula | C22H22FN3O3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1174043-16-3 |
PubChemID | 44199317 |
InChIKey | HYNBNUYQTQIHJK-UHFFFAOYSA-N |
Smiles | COC1CCN(C(C2=C(C=CC(CC3=NNC(C4=CC=CC=C34)=O)=C2)F)=O)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.54 | 100 | |
ethanol | 39.54 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight395.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.53mL | 12.64mL | 25.29mL |
5mM | 0.51mL | 2.53mL | 5.06mL |
10mM | 0.25mL | 1.26mL | 2.53mL |
50mM | 0.05mL | 0.25mL | 0.51mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
▍
品牌分类
▍
官网分类
▍
品牌问答
暂无品牌问答