Tocris现货代理 Tocris抗体,Tocris/Pomalidomide/6302/50/50 mg,连接酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Pomalidomide/6302/50/50 mg

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Tocris Bioscience

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6302/50

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4000-520-616

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Description:Cereblonubiquitinationinhibitor;alsoTNF-αinhibitorandantiangiogenic

ChemicalName:4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentTNF-αinhibitor(IC₅₀=13nM).AlsopotentlyinhibitsIL-2(EC₅₀=8nM).Thalidomidederivative.Bindscereblonandinhibitsitsubiquitination.ExhibitsantiproliferativeeffectsinaNamalwalymphomacellline.Antiangiogenic.

TechnicalData

M.Wt	273.24
Formula	C₁₃H₁₁N₃O₄
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	19171-19-8
PubChemID	134780
InChIKey	UVSMNLNDYGZFPF-UHFFFAOYSA-N
Smiles	NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	27.32	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight273.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.66mL	18.3mL	36.6mL
5mM	0.73mL	3.66mL	7.32mL
10mM	0.37mL	1.83mL	3.66mL
50mM	0.07mL	0.37mL	0.73mL

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BiologicalActivity

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