Tocris批发，产品货源 Tocris Bioscience一级代理,Tocris/A01/5397/10/10 mg,连接酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/A01/5397/10/10 mg

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Tocris Bioscience

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5397/10

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4000-520-616

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Description:HighaffinitySmurf1inhibitor;enhancesBMPsignaling

ChemicalName:[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinitySmurf1E3ubiquitinligaseinhibitor(K_d=3.7nM).AttenuatesSmurf1-mediatedSmad1/5degradationandenhancesBMPsignaling.PotentiatesBMP-2-inducedosteoblasticactivityinC2C12myoblastsandMC3T3-E1osteoblastprecursorcells.

TechnicalData

M.Wt	512.93
Formula	C₂₂H₂₀ClF₃N₄O₃S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1007647-73-5
PubChemID	17555704
InChIKey	QFYLTUDRXBNZFQ-UHFFFAOYSA-N
Smiles	ClC1=C(C(F)(F)F)C=C(S(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)(=O)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	51.29	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight512.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.95mL	9.75mL	19.5mL
5mM	0.39mL	1.95mL	3.9mL
10mM	0.19mL	0.97mL	1.95mL
50mM	0.04mL	0.19mL	0.39mL

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