BiologicalActivity
NoncompetitiveinhibitorofPCAFandp300histoneacetyltransferase(HAT)activity(IC50valuesare~5.0and~8.5μMrespectively).InhibitsNF-κBactivation.AlsoreportedtoselectivelyactivateAurorakinaseA-mediatedphosphorylationofhistoneH3andtoinhibitproteinSUMOylation.Exhibitsantitumor,antimicrobialandantioxidantactivity.
TechnicalData
| M.Wt | 348.52 |
| Formula | C22H36O3 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 16611-84-0 |
| PubChemID | 167551 |
| InChIKey | ADFWQBGTDJIESE-UHFFFAOYSA-N |
| Smiles | OC1=C(C(O)=O)C(CCCCCCCCCCCCCCC)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.85 | 100 | |
| ethanol | 17.43 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight348.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.87mL | 14.35mL | 28.69mL |
| 5mM | 0.57mL | 2.87mL | 5.74mL |
| 10mM | 0.29mL | 1.43mL | 2.87mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
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