BiologicalActivity
Antimalarialagent;interactswithhemetoproducecarbon-centredfreerADIcals,causesproteinalkylationanddamagesparasitemicroorganellesandmembranes.AlsoselectivelyinhibitstheP-typeATPase(PfATP6)ofPlasmodiumfalciparum(Ki~150nM).Displaysantiangiogeniceffectsinmouseembryonicstemcell-derivedembryoidbodies.
CompoundLibraries
ArtemisininisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 282.33 |
| Formula | C15H22O5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 63968-64-9 |
| PubChemID | 68827 |
| InChIKey | BLUAFEHZUWYNDE-NNWCWBAJSA-N |
| Smiles | O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.23 | 100 | |
| ethanol | 21.17 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight282.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.54mL | 17.71mL | 35.42mL |
| 5mM | 0.71mL | 3.54mL | 7.08mL |
| 10mM | 0.35mL | 1.77mL | 3.54mL |
| 50mM | 0.07mL | 0.35mL | 0.71mL |
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