BiologicalActivity
IrreversIBLeinhibitorofornithinedecarboxylase(ODC)thatinhibitspolyaminebiosynthesis.Displaysantiapoptotic,antiangiogenicandantiparasiticactivity.Inducesre-expressionofaberrantlysilencedtumorsuppressorgeneswhenusedincombinationwitholigoamineanalogs.
TechnicalData
| M.Wt | 218.63 |
| Formula | C6H12F2N2O2.HCl |
| Storage | DesiccateatRT |
| CASNumber | 68278-23-9 |
| PubChemID | 57004 |
| InChIKey | VKDGNNYJFSHYKD-UHFFFAOYSA-N |
| Smiles | NC(C(F)F)(C(O)=O)CCCN.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.4 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight218.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.57mL | 22.87mL | 45.74mL |
| 5mM | 0.91mL | 4.57mL | 9.15mL |
| 10mM | 0.46mL | 2.29mL | 4.57mL |
| 50mM | 0.09mL | 0.46mL | 0.91mL |
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