BiologicalActivity
Potentandselectivedopamineβ-hydroxylase(DBH)inhibitor(IC50=9nM).SelectiveforDBHover12otherenzymes.Decreasesnoradrenalineandincreasesdopaminelevelsintissuesandplasmainhypertensiverats.Preventsprogressiveleftventriculardysfunctioninaninvivoheartfailuremodel.Alsopotentiatesthestimuluseffectsofcocainewithoutproducingcocaine-likeeffectsinrats.Orallybioavailable.
TechnicalData
| M.Wt | 331.81 |
| Formula | C14H15F2N3S.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 170151-24-3 |
| PubChemID | 9840545 |
| InChIKey | DIPDUAJWNBEVOY-PPHPATTJSA-N |
| Smiles | S=C(NC=C3CN)N3[C@H]2CCC1=C(F)C=C(F)C=C1C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.18 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight331.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.01mL | 15.07mL | 30.14mL |
| 5mM | 0.6mL | 3.01mL | 6.03mL |
| 10mM | 0.3mL | 1.51mL | 3.01mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
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