Tocris型号参数规格 Tocris抗体,Tocris/RN 1 dihydrochloride/4977/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/RN 1 dihydrochloride/4977/10/10 mg

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Tocris/RN 1 dihydrochloride/4977/10/10 mg

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Tocris Bioscience

货号 /

4977/10

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4000-520-616

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Description:LSD1inhibitor

ChemicalName:1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanonedihydrochloride

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentlysinespecificdemethylase1(LSD1)inhibitor(IC₅₀=70nM).ExhibitsselectivityforLSD1overMAO-AandMAO-B(IC₅₀valuesare0.51and2.79μMforMAO-AandMAO-B,respectively).Impairslong-term,butnotshort-termmemoryinmice.BrainpenetrantfollowingsystemicadmiNISTration.

CompoundLibraries

RN1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	452.42
Formula	C₂₃H₂₉N₃O₂.2HCl
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	1781835-13-9
PubChemID	90488995
InChIKey	WMHAFZOOUBPQRX-VSIGASKDSA-N
Smiles	O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	9.05	20mMwithgentlewarming
	water	9.05	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight452.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.21mL	11.05mL	22.1mL
5mM	0.44mL	2.21mL	4.42mL
10mM	0.22mL	1.11mL	2.21mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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TechnicalData

SolubilityData

PreparingStockSolutions

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