BiologicalActivity
SelectiveinhibitorofCdc42.TargetsthebindingsiteoftheCdc42guaninenucleotideexchangefactor,intersectin(ITSN).InhibitsCdc42-mediatedcellulareffects,includingmicrospikeformationin3T3fibroblastsandneuronalbranchinginprimaryneonatalcorticalneurons.AlsosuppressescellmotilityandmigrationinPC3cells,withoutcytotoxiceffects.
CompoundLibraries
ZCL278isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 584.89 |
| Formula | C21H19BrClN5O4S2 |
| Storage | Storeat+4°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 587841-73-4 |
| PubChemID | 1791111 |
| InChIKey | XKZDWYDHEBCGCG-UHFFFAOYSA-N |
| Smiles | ClC1=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=CC(Br)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.49 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight584.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.71mL | 8.55mL | 17.1mL |
| 5mM | 0.34mL | 1.71mL | 3.42mL |
| 10mM | 0.17mL | 0.85mL | 1.71mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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