BiologicalActivity
Orallyactive5-lipoxygenase(5-LOX)inhibitorthatinhibitsLTB4synthesis(IC50valuesare0.56,2.3and2.6μMindog,ratandhumanbloodrespectively).Inhibitsantigen-inducedcontractionoftrachealstripsinvitro(IC50=6μM)andexhibitsantiasthmaticactivityinvivo.AlsoweaklyinhibitsCYP1A2(Ki=66-98μM).
CompoundLibraries
ZileutonisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 236.29 |
| Formula | C11H12N2O2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 111406-87-2 |
| PubChemID | 60490 |
| InChIKey | MWLSOWXNZPKENC-UHFFFAOYSA-N |
| Smiles | CC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight236.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.23mL | 21.16mL | 42.32mL |
| 5mM | 0.85mL | 4.23mL | 8.46mL |
| 10mM | 0.42mL | 2.12mL | 4.23mL |
| 50mM | 0.08mL | 0.42mL | 0.85mL |
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