BiologicalActivity
Potent,selectiveinhibitorofCdc25dualspecificityphosphatases(Kivaluesare29,95and89nMforhumanCdc25A,Cdc25B2andCdc25Crespectively);>20-and>450-foldselectiveoverVHRandPTP1Bphosphatasesrespectively.ArrestscellsatbothG1andG2/Mphaseandblockscdk2andcdk1activation.Blocksproliferationofarangeofhumantumorcelllines(IC50=0.2-35μM).
CompoundLibraries
NSC663284isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 321.76 |
| Formula | C15H16ClN3O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 383907-43-5 |
| PubChemID | 379077 |
| InChIKey | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
| Smiles | ClC1=C(NCCN2CCOCC2)C(=O)C2=NC=CC=C2C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.1 | 50 | |
| ethanol | 16.1 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight321.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.11mL | 15.54mL | 31.08mL |
| 5mM | 0.62mL | 3.11mL | 6.22mL |
| 10mM | 0.31mL | 1.55mL | 3.11mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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