BiologicalActivity
SelectiveSHIP2(SH2domain-containinginositol5'-phosphatase2)inhibitor(IC50valuesare0.34μMand0.62μMformouseandhumanrespectively);displaysapproximately30-foldaffinityforSHIP2overSHIP1.Increasesinsulin-inducedphosphorylationofAktinL6myotubules.Stimulatesactivationofglucosemetabolism;regulatesgluconeogenesisinvitroandinvivoandexhibitsantidiabeticeffects.
CompoundLibraries
AS1949490isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 371.88 |
| Formula | C20H18ClNO2S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1203680-76-5 |
| PubChemID | 44473434 |
| InChIKey | RFZPGNRLOKVZJY-AWEZNQCLSA-N |
| Smiles | ClC(C=C2)=CC=C2COC1=C(C(N[C@@H](C)C3=CC=CC=C3)=O)SC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.19 | 100 | |
| ethanol | 37.19 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.45mL | 26.89mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.34mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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