Description
AmlodipineisadihydropyridineL-typeCa2+channelblockerthatexhibitsantihypertensive,anti-anginal,andvasodilatoryactivities.Amlodipineisclinicallyusedtotreathypertensionandanginaasitinducesrelaxationofarterialsmoothmuscles,decreasesbloodpressure,andincreasesbloodflowtotheheart.Amlodipinealsoinhibitsacidsphingomyelinase(FIASMA),whichisinvolvedinprogrammedcelldeath.Additionally,thiscompoundimprovessmoothmusclehypertrophyandcollagendeposition,preventingarterialremodelinginhypertensiverats.
References
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